HCSGD entry for UBN1
1. General information
| Official gene symbol | UBN1 |
|---|---|
| Entrez ID | 29855 |
| Gene full name | ubinuclein 1 |
| Other gene symbols | VT VT4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA TAS | cellular_component |
| GO:0005923 | Tight junction | IEA ISS | cellular_component |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0010923 | Negative regulation of phosphatase activity | IDA | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0016605 | PML body | IEA | cellular_component |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0259224801 | 0.9668398883 | 0.3765483444 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3723039558 |
| GSE13712_SHEAR | Down | -0.1636044081 |
| GSE13712_STATIC | Down | -0.4504141970 |
| GSE19018 | Down | -0.0483430876 |
| GSE19899_A1 | Up | 0.3029116896 |
| GSE19899_A2 | Up | 0.4041907560 |
| PubMed_21979375_A1 | Up | 0.1438930830 |
| PubMed_21979375_A2 | Up | 0.5562987259 |
| GSE35957 | Down | -0.2172570126 |
| GSE36640 | Down | -0.0519113716 |
| GSE54402 | Up | 0.3723479547 |
| GSE9593 | Down | -0.0151681087 |
| GSE43922 | Up | 0.3791721951 |
| GSE24585 | Up | 0.3339501057 |
| GSE37065 | Down | -0.0959274341 |
| GSE28863_A1 | Up | 0.7708289869 |
| GSE28863_A2 | Up | 0.6775596523 |
| GSE28863_A3 | Up | 0.1014282031 |
| GSE28863_A4 | Up | 0.1005355752 |
| GSE48662 | Up | 0.3933204248 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017200 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040198 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040978 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048870 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27217568 | The histone chaperone HIRA complex, consisting of histone cell cycle regulator (HIRA), Ubinuclein1 (UBN1), and calcineurin binding protein 1 (CABIN1), deposits histone variant H3 |
| 27217568 | Here, we show that O-linked N-acetylglucosamine (GlcNAc) transferase (OGT), an enzyme that catalyzes O-GlcNAcylation of serine or threonine residues, interacts with UBN1, modifies HIRA, and promotes nucleosome assembly of H3 |
| 19029251 | Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells |
| 19029251 | Using a sophisticated approach to search for remote orthologs conserved in multiple species through evolution, we identified the HIRA-associated proteins, UBN1 and UBN2, as candidate human orthologs of Hpc2p |
| 19029251 | We show that the Hpc2-related domain of UBN1, UBN2, and Hpc2p is an evolutionarily conserved HIRA/Hir-binding domain, which directly interacts with the N-terminal WD repeats of HIRA/Hir |
| 19029251 | UBN1 binds to proliferation-promoting genes that are repressed by SAHF and associates with histone methyltransferase activity that methylates lysine 9 of histone H3, a site that is methylated in SAHF |
| 19029251 | UBN1 is indispensable for formation of SAHF |
| 19029251 | We conclude that UBN1 is an ortholog of yeast Hpc2p and a novel regulator of senescence |
Entries Per Page
Displaying Page of
