HCSGD entry for ICOS

1. General information

Official gene symbolICOS
Entrez ID29851
Gene full nameinducible T-cell co-stimulator
Other gene symbolsAILIM CD278 CVID1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002517T cell tolerance inductionIEAbiological_process
GO:0005576Extracellular regionIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIEAcellular_component
GO:0006955Immune responseNASbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0016337Cell-cell adhesionIEAbiological_process
GO:0031295T cell costimulationTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.25992195970.92940830520.95313174091.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0509832220
GSE13712_SHEARUp0.0608683534
GSE13712_STATICUp0.1867305678
GSE19018Up0.0170166295
GSE19899_A1Up0.2005607863
GSE19899_A2Up0.2571255968
PubMed_21979375_A1Up0.3531909640
PubMed_21979375_A2Up0.0419471119
GSE35957Up0.4970058405
GSE36640Down-0.0396998348
GSE54402Up0.0030096326
GSE9593Up0.0362301507
GSE43922Up0.0197891741
GSE24585Up0.0782654010
GSE37065Down-0.0122054629
GSE28863_A1Down-0.2634290300
GSE28863_A2Up0.0587022900
GSE28863_A3Up0.1349538804
GSE28863_A4Up0.2059932117
GSE48662Up0.0648590071

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-101-3pMIMAT00000991hsa-miR-10118172933
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.