HCSGD entry for SENP1
1. General information
| Official gene symbol | SENP1 |
|---|---|
| Entrez ID | 29843 |
| Gene full name | SUMO1/sentrin specific peptidase 1 |
| Other gene symbols | SuPr-2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004175 | Endopeptidase activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | IMP | biological_process |
| GO:0010724 | Regulation of definitive erythrocyte differentiation | IEA | biological_process |
| GO:0016925 | Protein sumoylation | TAS | biological_process |
| GO:0016926 | Protein desumoylation | IEA ISS | biological_process |
| GO:0016929 | SUMO-specific protease activity | IEA ISS | molecular_function |
| GO:0032435 | Negative regulation of proteasomal ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IGI | biological_process |
| GO:0097190 | Apoptotic signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9878116143 | 0.0064953345 | 0.9999902473 | 0.1636646226 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0894605163 |
| GSE13712_SHEAR | Up | 0.0505323608 |
| GSE13712_STATIC | Down | -0.0867490556 |
| GSE19018 | Down | -0.5678517890 |
| GSE19899_A1 | Down | -0.2029145072 |
| GSE19899_A2 | Down | -1.3187457155 |
| PubMed_21979375_A1 | Down | -1.1164352006 |
| PubMed_21979375_A2 | Down | -1.0865601482 |
| GSE35957 | Down | -0.5159252596 |
| GSE36640 | Down | -1.5912475163 |
| GSE54402 | Down | -0.0692625952 |
| GSE9593 | Down | -0.1802563929 |
| GSE43922 | Down | -0.4641085045 |
| GSE24585 | Up | 0.1878219320 |
| GSE37065 | Up | 0.1295474462 |
| GSE28863_A1 | Down | -0.1220561255 |
| GSE28863_A2 | Down | -0.0708872118 |
| GSE28863_A3 | Down | -0.7877700120 |
| GSE28863_A4 | Up | 0.1408219958 |
| GSE48662 | Down | -0.3592650346 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016404 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-375 | MIMAT0000728 | MIRT019847 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-133a-3p | MIMAT0000427 | MIRT021701 | Microarray | Functional MTI (Weak) | 21396852 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT025028 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025428 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026415 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040813 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26826302 | DESIGN: Expression of small ubiquitin-like modifier (SUMO) molecules, SUMO E1 activating enzymes SAE1 and SAE2, SUMO E2 conjugating enzyme UBC9, and de-sumoylation enzyme sentrin/SUMO-specific proteases (SENP)1 was immunolocalized in rat intervertebral disc (IVD) cells |
| 26826302 | Loss of function study using SENP1 siRNA was performed to investigate the regulatory role of sumoylation on the function of hypoxia inducible factor 1alpha (HIF-1alpha) and the hypoxic tolerance of IVD cells |
| 26826302 | Both NP and AF cells maintained viability under hypoxia and upregulated the expression of SENP1 |
| 26826302 | Although downregulation of SENP1 decreased the transcriptional activity of HIF-1alpha, the viability of disc cells showed no significant loss under hypoxia |
| 25483338 | The underlying mechanisms for this process involve the induction of miR-20a-5p expression, which targets SENP1, a key protein in the regulation of the SUMOylation process |
| 25483338 | These results are consistent with the expression of SENP1, miR-20a-5p and growth factors that are observed in a CRC mouse model and in human CCR biopsies colonized by pks+ E |
| 24658599 | The underlying mechanisms involve microRNA-20a-5p, which targets SENP1, a key protein regulating p53 deSUMOylation |
| 24658599 | These results are consistent with the expression of SENP1, microRNA-20a-5p, HGF and phosphorylation of HGF receptor found in human and mouse colon cancers colonised by pks+ E |
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