HCSGD entry for GUCY2C
1. General information
| Official gene symbol | GUCY2C |
|---|---|
| Entrez ID | 2984 |
| Gene full name | guanylate cyclase 2C (heat stable enterotoxin receptor) |
| Other gene symbols | DIAR6 GUC2C MECIL MUCIL STAR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004383 | Guanylate cyclase activity | IEA | molecular_function |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0007168 | Receptor guanylyl cyclase signaling pathway | TAS | biological_process |
| GO:0009636 | Response to toxic substance | IEA | biological_process |
| GO:0015643 | Toxic substance binding | IEA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0042127 | Regulation of cell proliferation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5755654230 | 0.8847923407 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0735038340 |
| GSE13712_SHEAR | Down | -0.0797870708 |
| GSE13712_STATIC | Up | 0.1517992538 |
| GSE19018 | Up | 0.1946299117 |
| GSE19899_A1 | Up | 0.0368903851 |
| GSE19899_A2 | Down | -0.1504585266 |
| PubMed_21979375_A1 | Down | -0.1287710874 |
| PubMed_21979375_A2 | Up | 0.5292906357 |
| GSE35957 | Up | 0.1075341445 |
| GSE36640 | Up | 0.0472094987 |
| GSE54402 | Down | -0.0761343979 |
| GSE9593 | Up | 0.0238396908 |
| GSE43922 | Up | 0.0135543425 |
| GSE24585 | Up | 0.2697665049 |
| GSE37065 | Down | -0.0921056507 |
| GSE28863_A1 | Down | -0.0097914580 |
| GSE28863_A2 | Down | -0.0216878291 |
| GSE28863_A3 | Up | 0.0509606143 |
| GSE28863_A4 | Up | 0.0048145311 |
| GSE48662 | Up | 0.0620701214 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24217248 | Intestinal cell proliferation and senescence are regulated by receptor guanylyl cyclase C and p21 |
| 24217248 | Guanylyl cyclase C (GC-C) is expressed in intestinal epithelial cells and serves as the receptor for bacterial heat-stable enterotoxin (ST) peptides and the guanylin family of gastrointestinal hormones |
| 24217248 | Activation of GC-C by administration of ST to wild type, but not Gucy2c(-/-), mice resulted in a reduction in carcinogen-induced aberrant crypt foci formation |
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