HCSGD entry for NCAPH2
1. General information
| Official gene symbol | NCAPH2 |
|---|---|
| Entrez ID | 29781 |
| Gene full name | non-SMC condensin II complex, subunit H2 |
| Other gene symbols | CAPH2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005694 | Chromosome | IEA | cellular_component |
| GO:0030261 | Chromosome condensation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9202215379 | 0.3019313438 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0597760556 |
| GSE13712_SHEAR | Up | 0.0154736427 |
| GSE13712_STATIC | Down | -0.0900820606 |
| GSE19018 | Up | 0.0521553194 |
| GSE19899_A1 | Down | -0.1497561661 |
| GSE19899_A2 | Down | -0.4452245465 |
| PubMed_21979375_A1 | Up | 0.7090879081 |
| PubMed_21979375_A2 | Down | -0.3552885884 |
| GSE35957 | Down | -0.2048802385 |
| GSE36640 | Down | -0.1081405876 |
| GSE54402 | Up | 0.0794860077 |
| GSE9593 | Down | -0.1778377467 |
| GSE43922 | Up | 0.0570648139 |
| GSE24585 | Up | 0.0699643860 |
| GSE37065 | Down | -0.0427087196 |
| GSE28863_A1 | Down | -0.0713423935 |
| GSE28863_A2 | Up | 0.0644174730 |
| GSE28863_A3 | Down | -0.1360684544 |
| GSE28863_A4 | Up | 0.0549107299 |
| GSE48662 | Down | -0.4029741013 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016269 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022333 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26017022 | While the full-length hCAP-H2 associates with mitotic chromosomes, the DeltaN variant exists as an insoluble nuclear structure |
| 26017022 | When overexpressed, both hCAP-H2 isoforms assemble this nuclear architecture and induce senescence-associated heterochromatic foci (SAHF) |
| 26017022 | The hCAP-H2DeltaN protein accumulates as cells approach senescence, and hCAP-H2 knockdown inhibits oncogene-induced senescence |
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