HCSGD entry for GTF2H1

1. General information

Official gene symbolGTF2H1
Entrez ID2965
Gene full namegeneral transcription factor IIH, polypeptide 1, 62kDa
Other gene symbolsBTF2 P62 TFB1 TFIIH
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000079Regulation of cyclin-dependent protein serine/threonine kinase activityTASbiological_process
GO:0000439Core TFIIH complexIEAcellular_component
GO:0000718Nucleotide-excision repair, DNA damage removalTASbiological_process
GO:0004672Protein kinase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005675Holo TFIIH complexIDAcellular_component
GO:0006200ATP catabolic processIDAbiological_process
GO:0006281DNA repairTASbiological_process
GO:0006283Transcription-coupled nucleotide-excision repairTASbiological_process
GO:0006289Nucleotide-excision repairIEA TASbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006360Transcription from RNA polymerase I promoterTASbiological_process
GO:0006361Transcription initiation from RNA polymerase I promoterTASbiological_process
GO:0006362Transcription elongation from RNA polymerase I promoterTASbiological_process
GO:0006363Termination of RNA polymerase I transcriptionTASbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDA TASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006368Transcription elongation from RNA polymerase II promoterTASbiological_process
GO:00063707-methylguanosine mRNA cappingTASbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0008094DNA-dependent ATPase activityIDAmolecular_function
GO:0008353RNA polymerase II carboxy-terminal domain kinase activityIDAmolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016310PhosphorylationIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0050434Positive regulation of viral transcriptionTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.15341068350.88539517120.77996389421.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1399145505
GSE13712_SHEARDown-0.1090538917
GSE13712_STATICUp0.0800476360
GSE19018Down-0.5392113830
GSE19899_A1Up0.3523986424
GSE19899_A2Up0.2765010324
PubMed_21979375_A1Up0.4795121449
PubMed_21979375_A2Up0.2730230033
GSE35957Up0.0896253880
GSE36640Up0.2417936669
GSE54402Up0.1542665422
GSE9593Up0.3153040107
GSE43922Up0.0123926692
GSE24585Up0.0118733942
GSE37065Down-0.0487314488
GSE28863_A1Up0.2410032825
GSE28863_A2Up0.3695177165
GSE28863_A3Down-0.1189898432
GSE28863_A4Up0.0085817188
GSE48662Down-0.2968652740

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT000850MicroarrayFunctional MTI (Weak)18362358
hsa-miR-15a-5pMIMAT0000068MIRT000851MicroarrayFunctional MTI (Weak)18362358
hsa-miR-132-3pMIMAT0000426MIRT021862MicroarrayFunctional MTI (Weak)17612493
hsa-miR-1MIMAT0000416MIRT024028ProteomicsFunctional MTI (Weak)18668040
hsa-miR-30a-5pMIMAT0000087MIRT028676ProteomicsFunctional MTI (Weak)18668040
hsa-miR-100-5pMIMAT0000098MIRT048496CLASHFunctional MTI (Weak)23622248
hsa-miR-99a-5pMIMAT0000097MIRT048641CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-15a-5pMIMAT0000068NAhsa-miR-15a18362358
hsa-miR-16-5pMIMAT0000069NAhsa-miR-1618362358
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.