HCSGD entry for GTF2B
1. General information
| Official gene symbol | GTF2B |
|---|---|
| Entrez ID | 2959 |
| Gene full name | general transcription factor IIB |
| Other gene symbols | TF2B TFIIB |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001047 | Core promoter binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006352 | DNA-templated transcription, initiation | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0006368 | Transcription elongation from RNA polymerase II promoter | TAS | biological_process |
| GO:0008134 | Transcription factor binding | IPI | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0017025 | TBP-class protein binding | IEA | molecular_function |
| GO:0046966 | Thyroid hormone receptor binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0179356103 | 0.7867490369 | 0.3284121001 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3990328759 |
| GSE13712_SHEAR | Up | 0.0096435540 |
| GSE13712_STATIC | Up | 0.0533995258 |
| GSE19018 | Down | -0.4340087060 |
| GSE19899_A1 | Up | 0.9511769200 |
| GSE19899_A2 | Up | 0.7526377594 |
| PubMed_21979375_A1 | Up | 0.5917934279 |
| PubMed_21979375_A2 | Up | 0.7672332376 |
| GSE35957 | Down | -0.2727306938 |
| GSE36640 | Up | 0.4631566565 |
| GSE54402 | Up | 0.5002672187 |
| GSE9593 | Down | -0.2701970146 |
| GSE43922 | Up | 0.5383764907 |
| GSE24585 | Up | 0.4951502081 |
| GSE37065 | Up | 0.3011930004 |
| GSE28863_A1 | Up | 0.0207718042 |
| GSE28863_A2 | Up | 0.3929918366 |
| GSE28863_A3 | Down | -0.4563871823 |
| GSE28863_A4 | Down | -0.1600305276 |
| GSE48662 | Down | -0.3526986078 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT003079 | qRT-PCR | Functional MTI (Weak) | 18073344 |
| hsa-miR-484 | MIMAT0002174 | MIRT041771 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15236317 | The candidate genes PRKCL2 and GTF2B, within SRO2, and TGFBR3, CDC7, and EVI5, in a broad region encompassing SRO3, were screened in 1p22-linked melanoma kindreds, but no coding mutations were detected |
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