HCSGD entry for MSH6

1. General information

Official gene symbolMSH6
Entrez ID2956
Gene full namemutS homolog 6 (E. coli)
Other gene symbolsGTBP HNPCC5 HSAP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000228Nuclear chromosomeIBAcellular_component
GO:0000287Magnesium ion bindingIDAmolecular_function
GO:0000400Four-way junction DNA bindingIDAmolecular_function
GO:0000710Meiotic mismatch repairIBA ISSbiological_process
GO:0000790Nuclear chromatinIEAcellular_component
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003684Damaged DNA bindingIEAmolecular_function
GO:0003690Double-stranded DNA bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0006200ATP catabolic processIBA IDAbiological_process
GO:0006281DNA repairIDAbiological_process
GO:0006298Mismatch repairIDA IEA IGI IMPbiological_process
GO:0007131Reciprocal meiotic recombinationIBAbiological_process
GO:0008094DNA-dependent ATPase activityIBAmolecular_function
GO:0008340Determination of adult lifespanIEA ISSbiological_process
GO:0008630Intrinsic apoptotic signaling pathway in response to DNA damageIBA IEA ISSbiological_process
GO:0009411Response to UVIBA IEA ISSbiological_process
GO:0016446Somatic hypermutation of immunoglobulin genesIBA IEA ISSbiological_process
GO:0016447Somatic recombination of immunoglobulin gene segmentsISSbiological_process
GO:0016887ATPase activityIDAmolecular_function
GO:0030983Mismatched DNA bindingIDA IEAmolecular_function
GO:0032137Guanine/thymine mispair bindingIDA IEAmolecular_function
GO:0032142Single guanine insertion bindingIDAmolecular_function
GO:0032143Single thymine insertion bindingIDAmolecular_function
GO:0032301MutSalpha complexIDA IEAcellular_component
GO:0032357Oxidized purine DNA bindingIDAmolecular_function
GO:0032405MutLalpha complex bindingIDAmolecular_function
GO:0035064Methylated histone residue bindingIDAmolecular_function
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043531ADP bindingIDAmolecular_function
GO:0043570Maintenance of DNA repeat elementsIMPbiological_process
GO:0045190Isotype switchingIBA IEA ISSbiological_process
GO:0045910Negative regulation of DNA recombinationIDA IEAbiological_process
GO:0051096Positive regulation of helicase activityIDAbiological_process
GO:0097193Intrinsic apoptotic signaling pathwayISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99195563620.00494208050.99999024730.1427886937

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4356747294
GSE13712_SHEARDown-0.3961818574
GSE13712_STATICDown-0.2153714211
GSE19018Up0.0785449113
GSE19899_A1Down-0.5290056379
GSE19899_A2Down-0.8073400740
PubMed_21979375_A1Down-0.6977069168
PubMed_21979375_A2Down-1.0175269631
GSE35957Down-0.4157530149
GSE36640Down-1.2826823828
GSE54402Down-0.0230516134
GSE9593Down-0.3337370144
GSE43922Down-0.4560827397
GSE24585Down-0.4005326869
GSE37065Down-0.0837697924
GSE28863_A1Up0.1604625661
GSE28863_A2Up0.4536703266
GSE28863_A3Down-0.3201715676
GSE28863_A4Down-0.1648356691
GSE48662Down-0.5905072645

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT000459Luciferase reporter assay//Western blot//Northern blotFunctional MTI20351277
hsa-miR-21-5pMIMAT0000076MIRT005430Luciferase reporter assay//Northern blot//qRT-PCR//Western blotFunctional MTI21078976
hsa-miR-193b-3pMIMAT0002819MIRT016477MicroarrayFunctional MTI (Weak)20304954
hsa-miR-1MIMAT0000416MIRT023763ProteomicsFunctional MTI (Weak)18668040
hsa-miR-215-5pMIMAT0000272MIRT024435MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026596MicroarrayFunctional MTI (Weak)19074876
hsa-miR-877-3pMIMAT0004950MIRT037190CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT039671CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041744CLASHFunctional MTI (Weak)23622248
hsa-miR-196b-5pMIMAT0001080MIRT042692CLASHFunctional MTI (Weak)23622248
hsa-miR-324-3pMIMAT0000762MIRT042967CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043139CLASHFunctional MTI (Weak)23622248
hsa-miR-106b-5pMIMAT0000680MIRT044304CLASHFunctional MTI (Weak)23622248
hsa-miR-23b-3pMIMAT0000418MIRT046243CLASHFunctional MTI (Weak)23622248
hsa-miR-26a-5pMIMAT0000082MIRT050169CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23383259Studies with mismatch repair mutants and MSH6, Rad51 and ATM knockdowns revealed that autophagy induced by O(6)MeG requires mismatch repair and ATM, and is counteracted by homologous recombination
18567801Western blot and immunohistochemistry analysis revealed that hMSH2 and MSH6 protein (MutS alpha complex), which is a known key component in the MMR pathway, is markedly down-regulated in senescent cells
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