HCSGD entry for GSTA4
1. General information
| Official gene symbol | GSTA4 |
|---|---|
| Entrez ID | 2941 |
| Gene full name | glutathione S-transferase alpha 4 |
| Other gene symbols | GSTA4-4 GTA4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004364 | Glutathione transferase activity | IDA IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006749 | Glutathione metabolic process | IDA | biological_process |
| GO:0006805 | Xenobiotic metabolic process | IDA TAS | biological_process |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:1901687 | Glutathione derivative biosynthetic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7746593367 | 0.0208642567 | 0.9999902473 | 0.2791906965 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0424167779 |
| GSE13712_SHEAR | Down | -0.4257302117 |
| GSE13712_STATIC | Down | -0.0638216127 |
| GSE19018 | Up | 0.3962022567 |
| GSE19899_A1 | Down | -0.0993265496 |
| GSE19899_A2 | Down | -1.0390785504 |
| PubMed_21979375_A1 | Down | -1.3501357933 |
| PubMed_21979375_A2 | Down | -0.4040705692 |
| GSE35957 | Up | 0.3309024000 |
| GSE36640 | Up | 0.8896648811 |
| GSE54402 | Down | -0.5862443747 |
| GSE9593 | Down | -0.5978953333 |
| GSE43922 | Down | -0.5633434421 |
| GSE24585 | Up | 0.1764211016 |
| GSE37065 | Down | -0.4612687708 |
| GSE28863_A1 | Up | 0.3932645949 |
| GSE28863_A2 | Up | 0.2002846216 |
| GSE28863_A3 | Down | -0.5103862842 |
| GSE28863_A4 | Down | -0.2615234252 |
| GSE48662 | Down | -0.1190398222 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Glutathione | DB00143 | NUTR00029 | EXPT01650 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-185-5p | MIMAT0000455 | MIRT045335 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24788960 | Our RT-PCR result demonstrates that Klf4(-/-) MEFs have decreased expression of the antioxidant gene, Gsta4 |
| 24788960 | The downregulation of the Gsta4 correlates with significant levels of ROS accumulation, as shown by DCFDA and FACS analysis, and thus the oxidative stress-induced premature senescence |
| 24788960 | Together these findings suggest a mechanism by which KLF4 protects against DNA damage and oxidative stress at least in part through the regulation of Gsta4 and likely related genes |
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