HCSGD entry for GSPT1
1. General information
| Official gene symbol | GSPT1 |
|---|---|
| Entrez ID | 2935 |
| Gene full name | G1 to S phase transition 1 |
| Other gene symbols | 551G9.2 ETF3A GST1 eRF3a |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000184 | Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | biological_process |
| GO:0003747 | Translation release factor activity | IMP | molecular_function |
| GO:0003924 | GTPase activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005622 | Intracellular | NAS | cellular_component |
| GO:0006184 | GTP catabolic process | TAS | biological_process |
| GO:0006415 | Translational termination | IMP | biological_process |
| GO:0006479 | Protein methylation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9594834049 | 0.0410784165 | 0.9999902473 | 0.3817884887 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0983334075 |
| GSE13712_SHEAR | Down | -0.1169669599 |
| GSE13712_STATIC | Down | -0.1230457810 |
| GSE19018 | Down | -0.7014283995 |
| GSE19899_A1 | Down | -0.1533494815 |
| GSE19899_A2 | Down | -0.6120872119 |
| PubMed_21979375_A1 | Down | -0.3675554099 |
| PubMed_21979375_A2 | Down | -0.5715198909 |
| GSE35957 | Down | -0.1889621647 |
| GSE36640 | Down | -0.1523990591 |
| GSE54402 | Down | -0.0326062596 |
| GSE9593 | Up | 0.0094226488 |
| GSE43922 | Up | 0.0421959187 |
| GSE24585 | Down | -0.3629988380 |
| GSE37065 | Down | -0.0763799225 |
| GSE28863_A1 | Up | 0.1668842969 |
| GSE28863_A2 | Up | 0.4396250017 |
| GSE28863_A3 | Down | -0.5173758689 |
| GSE28863_A4 | Up | 0.2455012530 |
| GSE48662 | Down | -0.4532879495 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Guanosine-5'-Diphosphate | DB04315 | EXPT01573 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT032238 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-361-5p | MIMAT0000703 | MIRT044090 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047129 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
