HCSGD entry for GRPR
1. General information
| Official gene symbol | GRPR |
|---|---|
| Entrez ID | 2925 |
| Gene full name | gastrin-releasing peptide receptor |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004946 | Bombesin receptor activity | IEA | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0008528 | G-protein coupled peptide receptor activity | TAS | molecular_function |
| GO:0042127 | Regulation of cell proliferation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9704753847 | 0.0240919494 | 0.9999902473 | 0.2988332705 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0043672938 |
| GSE13712_SHEAR | Up | 0.0446658194 |
| GSE13712_STATIC | Down | -0.1294797867 |
| GSE19018 | Down | -0.2250730004 |
| GSE19899_A1 | Up | 0.0108130642 |
| GSE19899_A2 | Up | 0.1362889746 |
| PubMed_21979375_A1 | Down | -0.5983564010 |
| PubMed_21979375_A2 | Down | -0.7927337477 |
| GSE35957 | Up | 0.2297285752 |
| GSE36640 | Down | -1.0918672176 |
| GSE54402 | Up | 0.0150751640 |
| GSE9593 | Up | 0.0876880552 |
| GSE43922 | Down | -2.0469818345 |
| GSE24585 | Up | 0.0936899695 |
| GSE37065 | Down | -0.1112474851 |
| GSE28863_A1 | Down | -0.0747443605 |
| GSE28863_A2 | Down | -0.9088616666 |
| GSE28863_A3 | Down | -0.3891867828 |
| GSE28863_A4 | Up | 0.0431533578 |
| GSE48662 | Down | -0.0553169797 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-17-3p | MIMAT0000071 | MIRT050741 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26780458 | Gastrin-Releasing Peptide Receptor Knockdown Induces Senescence in Glioblastoma Cells |
| 26780458 | The activation of gastrin-releasing peptide receptors (GRPR) stimulates GBM cell proliferation, whereas GRPR antagonists induce antiproliferative effects in in vitro and in vivo experimental models of GBM |
| 26780458 | However, the role of GRPR in regulating other aspects of GBM cell function related to tumor progression remains poorly understood, and previous studies have not used RNA interference techniques as tools to examine GRPR function in GBM |
| 26780458 | Here, we found that stable GRPR knockdown by a lentiviral vector using a short hairpin interfering RNA sequence in human A172 GBM cells resulted in increased cell size and altered cell cycle dynamics consistent with cell senescence |
| 26780458 | These results increase our understanding of GRPR regulation of GBM cells and further support that GRPR may be a relevant therapeutic target in GBM |
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