HCSGD entry for CXCL1
1. General information
| Official gene symbol | CXCL1 |
|---|---|
| Entrez ID | 2919 |
| Gene full name | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
| Other gene symbols | FSP GRO1 GROa MGSA MGSA-a NAP-3 SCYB1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005102 | Receptor binding | TAS | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006935 | Chemotaxis | TAS | biological_process |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0006955 | Immune response | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0007399 | Nervous system development | TAS | biological_process |
| GO:0008009 | Chemokine activity | IEA | molecular_function |
| GO:0008047 | Enzyme activator activity | TAS | molecular_function |
| GO:0008083 | Growth factor activity | IEA | molecular_function |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0030036 | Actin cytoskeleton organization | TAS | biological_process |
| GO:0035556 | Intracellular signal transduction | TAS | biological_process |
| GO:0043085 | Positive regulation of catalytic activity | TAS | biological_process |
| GO:0050790 | Regulation of catalytic activity | TAS | biological_process |
| GO:0060326 | Cell chemotaxis | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0000107139 | 0.8090787584 | 0.0115777778 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.1349538533 |
| GSE13712_SHEAR | Up | 2.5393959438 |
| GSE13712_STATIC | Up | 1.0959626771 |
| GSE19018 | Down | -0.5562522555 |
| GSE19899_A1 | Up | 5.4001296616 |
| GSE19899_A2 | Up | 8.1480535315 |
| PubMed_21979375_A1 | Up | 9.5707232541 |
| PubMed_21979375_A2 | Up | 9.0260822549 |
| GSE35957 | Down | -1.0321636161 |
| GSE36640 | Up | 1.1658227035 |
| GSE54402 | Up | 0.2913326037 |
| GSE9593 | Down | -1.4434180318 |
| GSE43922 | Up | 3.2268617762 |
| GSE24585 | Up | 0.0778505573 |
| GSE37065 | Up | 1.5120599588 |
| GSE28863_A1 | Up | 0.5368781809 |
| GSE28863_A2 | Down | -0.2203366226 |
| GSE28863_A3 | Up | 0.5534852081 |
| GSE28863_A4 | Up | 0.2399481394 |
| GSE48662 | Up | 0.0659914137 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT023084 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT023999 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27092462 | Adiponectin induces CXCL1 secretion from cancer cells and promotes tumor angiogenesis by inducing stromal fibroblast senescence |
| 27092462 | A secretion of CXCL1 by adiponectin-treated tumor cells was observed during the process of inducing stromal fibroblast senescence |
| 27092462 | Taken together, our results indicate that adiponectin promotes stromal cell senescence within invasive colon cancer contributing to angiogenesis and tumor growth in part through the production of CXCL1 and may serve as a therapeutic target for tumor patients |
| 26433963 | In this report we show that senescent human peritoneal mesothelial cells (HPMCs) alter the secretory profile of ovarian cancer cells (A2780, OVCAR-3, SKOV-3) by increasing the release of four angiogenic agents: CXCL1, CXCL8, HGF, and VEGF |
| 23117626 | NF90 elicited these effects mainly by repressing the translation of target SASP mRNAs, since silencing NF90 did not increase the steady-state levels of SASP mRNAs but elevated key SASP factors including MCP-1, GROa, IL-6, and IL-8 |
| 18449211 | Microarray analysis revealed lower expression levels of several CXC chemokine genes (CXCL-1, -2, -3, -5, -6, -12) in CWF compared with NF (confirmed by ELISA) |
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