HCSGD entry for GRM5

1. General information

Official gene symbolGRM5
Entrez ID2915
Gene full nameglutamate receptor, metabotropic 5
Other gene symbolsGPRC1E MGLUR5 mGlu5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000185Activation of MAPKKK activityIEAbiological_process
GO:0002029Desensitization of G-protein coupled receptor protein signaling pathwayIEAbiological_process
GO:0004930G-protein coupled receptor activityIEA TASmolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIMPcellular_component
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006468Protein phosphorylationIEAbiological_process
GO:0007205Protein kinase C-activating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007206Phospholipase C-activating G-protein coupled glutamate receptor signaling pathwayTASbiological_process
GO:0007216G-protein coupled glutamate receptor signaling pathwayIMPbiological_process
GO:0007268Synaptic transmissionIEAbiological_process
GO:0007612LearningIEAbiological_process
GO:0007626Locomotory behaviorIEAbiological_process
GO:0008066Glutamate receptor activityIDAmolecular_function
GO:0014069Postsynaptic densityIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0031687A2A adenosine receptor bindingIEAmolecular_function
GO:0040013Negative regulation of locomotionIEAbiological_process
GO:0043197Dendritic spineIEAcellular_component
GO:0043198Dendritic shaftIEAcellular_component
GO:0048170Positive regulation of long-term neuronal synaptic plasticityIEAbiological_process
GO:0097449Astrocyte projectionIEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.80406456820.85690370810.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2243400141
GSE13712_SHEARDown-0.0297245782
GSE13712_STATICDown-0.0429838107
GSE19018Up0.0327328929
GSE19899_A1Up0.0781456545
GSE19899_A2Down-0.0529823290
PubMed_21979375_A1Up0.1507102826
PubMed_21979375_A2Up0.0854268476
GSE35957Up0.1494318076
GSE36640Up0.0024885216
GSE54402Up0.0898832264
GSE9593Down-0.0289256881
GSE43922Up0.0543691166
GSE24585Up0.1258852320
GSE37065Down-0.0173340204
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.1104584374

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AcamprosateDB00659 APRD00661
ADX10059DB05070 -
ADX-48621DB06060 -
RufinamideDB06201 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018632MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.