HCSGD entry for RACGAP1

1. General information

Official gene symbolRACGAP1
Entrez ID29127
Gene full nameRac GTPase activating protein 1
Other gene symbolsCYK4 HsCYK-4 ID-GAP MgcRacGAP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000281Mitotic cytokinesisIDA IMPbiological_process
GO:0000915Cytokinesis, actomyosin contractile ring assemblyIMPbiological_process
GO:0001669Acrosomal vesicleIEAcellular_component
GO:0005096GTPase activator activityIDA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005547Phosphatidylinositol-3,4,5-trisphosphate bindingIDAmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005874MicrotubuleIEAcellular_component
GO:0007018Microtubule-based movementTASbiological_process
GO:0007108Cytokinesis, initiation of separationIMPbiological_process
GO:0007165Signal transductionIEAbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0007283SpermatogenesisIEPbiological_process
GO:0007405Neuroblast proliferationIEA ISSbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008017Microtubule bindingIDAmolecular_function
GO:0008272Sulfate transportIDAbiological_process
GO:0009790Embryo developmentIEA ISSbiological_process
GO:0019886Antigen processing and presentation of exogenous peptide antigen via MHC class IITASbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030496MidbodyIDAcellular_component
GO:0031234Extrinsic component of cytoplasmic side of plasma membraneIDAcellular_component
GO:0032154Cleavage furrowIDAcellular_component
GO:0032467Positive regulation of cytokinesisIDA IMPbiological_process
GO:0043014Alpha-tubulin bindingIDAmolecular_function
GO:0043015Gamma-tubulin bindingIDAmolecular_function
GO:0043085Positive regulation of catalytic activityIDA IMPbiological_process
GO:0043547Positive regulation of GTPase activityIDA IMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048487Beta-tubulin bindingIDAmolecular_function
GO:0050790Regulation of catalytic activityIDA IMPbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0051233Spindle midzoneIDAcellular_component
GO:0051256Spindle midzone assembly involved in mitosisIDAbiological_process
GO:0051988Regulation of attachment of spindle microtubules to kinetochoreIMPbiological_process
GO:0072686Mitotic spindleIDA IMPcellular_component
GO:0097149Centralspindlin complexIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99234571250.00003429200.99999024730.0102625000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.6769870984
GSE13712_SHEARDown-0.0694402662
GSE13712_STATICDown-0.4041817153
GSE19018Up0.2869602192
GSE19899_A1Down-2.9845413649
GSE19899_A2Down-2.3064365191
PubMed_21979375_A1Down-2.7938202660
PubMed_21979375_A2Down-3.5553766375
GSE35957Down-2.3229242598
GSE36640Down-2.4994355132
GSE54402Down-0.9106535522
GSE9593Down-1.0148955566
GSE43922Down-1.6107731454
GSE24585Up0.0187516712
GSE37065Down-0.4660537933
GSE28863_A1Down-0.3068947276
GSE28863_A2Down-0.1408530293
GSE28863_A3Down-0.3330099733
GSE28863_A4Up0.1734636713
GSE48662Down-1.3294057517

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-192-5pMIMAT0000222MIRT004859Luciferase reporter assay//qRT-PCR//Microarray//Reporter assay;Microarray;OtherFunctional MTI19074876
hsa-miR-193b-3pMIMAT0002819MIRT016327MicroarrayFunctional MTI (Weak)20304954
hsa-miR-215-5pMIMAT0000272MIRT024375MicroarrayFunctional MTI (Weak)19074876
hsa-miR-26b-5pMIMAT0000083MIRT029047MicroarrayFunctional MTI (Weak)19088304
hsa-miR-16-5pMIMAT0000069MIRT031559ProteomicsFunctional MTI (Weak)18668040
hsa-miR-221-3pMIMAT0000278MIRT046942CLASHFunctional MTI (Weak)23622248
hsa-let-7e-5pMIMAT0000066MIRT051704CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25255445Microarray analysis revealed that in fibroblasts, EZH2 antagonizes a subset of p53 target genes previously associated with the senescent cell phenotype, including DEK and RacGAP1
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