HCSGD entry for CD274
1. General information
| Official gene symbol | CD274 |
|---|---|
| Entrez ID | 29126 |
| Gene full name | CD274 molecule |
| Other gene symbols | B7-H B7H1 PD-L1 PDCD1L1 PDCD1LG1 PDL1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006955 | Immune response | IDA | biological_process |
| GO:0007165 | Signal transduction | IDA | biological_process |
| GO:0007166 | Cell surface receptor signaling pathway | IDA | biological_process |
| GO:0009897 | External side of plasma membrane | IEA | cellular_component |
| GO:0012505 | Endomembrane system | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0031295 | T cell costimulation | IDA TAS | biological_process |
| GO:0042102 | Positive regulation of T cell proliferation | TAS | biological_process |
| GO:0042130 | Negative regulation of T cell proliferation | IEA | biological_process |
| GO:0070062 | Extracellular vesicular exosome | IDA | cellular_component |
| GO:2001181 | Positive regulation of interleukin-10 secretion | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0108651685 | 0.1264792903 | 0.2636234807 | 0.6848387256 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5890196484 |
| GSE13712_SHEAR | Up | 1.4255733295 |
| GSE13712_STATIC | Up | 0.3993651232 |
| GSE19018 | Down | -0.7017966176 |
| GSE19899_A1 | Up | 0.4871188801 |
| GSE19899_A2 | Up | 0.2729592102 |
| PubMed_21979375_A1 | Up | 2.3923984683 |
| PubMed_21979375_A2 | Down | -0.0866256145 |
| GSE35957 | Down | -0.8586898874 |
| GSE36640 | Down | -0.8575075993 |
| GSE54402 | Up | 0.4627602755 |
| GSE9593 | Down | -0.0187639793 |
| GSE43922 | Up | 1.3453116662 |
| GSE24585 | Up | 0.7291030092 |
| GSE37065 | Up | 1.1258662264 |
| GSE28863_A1 | Down | -0.3921597904 |
| GSE28863_A2 | Down | -0.4034873192 |
| GSE28863_A3 | Down | -0.1931215060 |
| GSE28863_A4 | Down | -0.0702557077 |
| GSE48662 | Down | -0.1214825582 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Atezolizumab | DB11595 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-513a-5p | MIMAT0002877 | MIRT003923 | Luciferase reporter assay//Western blot | Functional MTI | 19155478 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027156 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031920 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-513a-5p | MIMAT0002877 | 1 | hsa-miR-513a-5p | 19155478 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26434982 | In addition, we observed an age-dependent increase in the expression of Pdl1, encoding an immune suppressive ligand that promotes cancer immune evasion |
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