HCSGD entry for TBK1

1. General information

Official gene symbolTBK1
Entrez ID29110
Gene full nameTANK-binding kinase 1
Other gene symbolsNAK T2K
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002218Activation of innate immune responseIEAbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0004672Protein kinase activityIEA TASmolecular_function
GO:0004674Protein serine/threonine kinase activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006954Inflammatory responseTASbiological_process
GO:0007249I-kappaB kinase/NF-kappaB signalingTASbiological_process
GO:0009615Response to virusTASbiological_process
GO:0010008Endosome membraneTAScellular_component
GO:0010629Negative regulation of gene expressionIEAbiological_process
GO:0016032Viral processIEAbiological_process
GO:0032480Negative regulation of type I interferon productionTASbiological_process
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0032606Type I interferon productionTASbiological_process
GO:0032727Positive regulation of interferon-alpha productionIDAbiological_process
GO:0032728Positive regulation of interferon-beta productionIDAbiological_process
GO:0033138Positive regulation of peptidyl-serine phosphorylationNASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEPbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045359Positive regulation of interferon-beta biosynthetic processIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0050830Defense response to Gram-positive bacteriumIEAbiological_process
GO:0051219Phosphoprotein bindingIPImolecular_function
GO:0051607Defense response to virusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09730556970.71120533790.65254961791.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3599894698
GSE13712_SHEARUp0.1086251465
GSE13712_STATICUp0.0827033125
GSE19018Up0.0005729742
GSE19899_A1Up0.0294937664
GSE19899_A2Up0.2976605407
PubMed_21979375_A1Down-0.0410032994
PubMed_21979375_A2Up0.4147928180
GSE35957Up0.1364149649
GSE36640Up0.4513268075
GSE54402Up0.5444033087
GSE9593Up0.0490725161
GSE43922Up0.1056578458
GSE24585Up0.0586997031
GSE37065Up0.5290706710
GSE28863_A1Down-0.0526818579
GSE28863_A2Up0.0616399463
GSE28863_A3Down-0.7589229787
GSE28863_A4Up0.2082560398
GSE48662Down-0.6298367675

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-221-3pMIMAT0000278MIRT003360Reporter assay;Western blot;MicroarrayFunctional MTI20018759
hsa-miR-200c-3pMIMAT0000617MIRT006971Luciferase reporter assay//Western blotFunctional MTI22991189
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-221-3pMIMAT0000278NAhsa-miR-221{Western blot}{overexpression by miRNA precursor transfection}20018759
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25594009Targeting HER2(+) breast cancer: the TBK1/IKKepsilon axis
25594009We performed a lenti-viral shRNA kinome screen on non-adherent mouse Her2/Neu tumorspheres and identified TBK1, a non-canonical IkappaB kinase (IKK), as the most potent target [1]
25594009TBK1 knock-down, or treatment with TBK1-II, a drug that efficiently inhibits TBK1 and its close relative IKKepsilon (IKBKE), suppressed growth of human HER2(+) BC cells and induced cellular senescence
25594009Thus, TBK1/IKKepsilon inhibitors may improve treatment of HER2(+) BC in cooperation with anti-HER2 therapy
24487029We identified kinases such as the mitogen-activated protein kinase and the TGFbetaR protein family, previously implicated in HER2(+) breast cancer, as well as autophagy factor ATG1/ULK1 and the noncanonical IkappaB kinase (IKK), TANK-binding kinase 1 (TBK1), which have not been previously linked to HER2(+) breast cancer
24487029Knockdown of TBK1 or pharmacologic inhibition of TBK1 and the related protein, IKKepsilon, suppressed growth of both mouse and human HER2(+) breast cancer cells
24487029TBK1/IKKepsilon inhibition promoted cellular senescence by suppressing p65-NF-kappaB and inducing p16(Ink4a)
24487029In addition, TBK1/IKKepsilon inhibition cooperated with lapatinib, a HER2/EGFR1-targeted drug, to accelerate apoptosis and kill HER2(+) breast cancer cells both in culture and in xenografts
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