HCSGD entry for PYCARD

1. General information

Official gene symbolPYCARD
Entrez ID29108
Gene full namePYD and CARD domain containing
Other gene symbolsASC CARD5 TMS TMS-1 TMS1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001773Myeloid dendritic cell activationIMPbiological_process
GO:0002218Activation of innate immune responseIDAbiological_process
GO:0002277Myeloid dendritic cell activation involved in immune responseISSbiological_process
GO:0002588Positive regulation of antigen processing and presentation of peptide antigen via MHC class IIISSbiological_process
GO:0002821Positive regulation of adaptive immune responseIMPbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusISScellular_component
GO:0005737CytoplasmIDA NAScellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006915Apoptotic processTASbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processNASbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0008385IkappaB kinase complexIDA TAScellular_component
GO:0008656Cysteine-type endopeptidase activator activity involved in apoptotic processNASmolecular_function
GO:0010803Regulation of tumor necrosis factor-mediated signaling pathwayIMPbiological_process
GO:0030838Positive regulation of actin filament polymerizationISSbiological_process
GO:0031647Regulation of protein stabilityISSbiological_process
GO:0032088Negative regulation of NF-kappaB transcription factor activityIMPbiological_process
GO:0032090Pyrin domain bindingIPImolecular_function
GO:0032688Negative regulation of interferon-beta productionIMPbiological_process
GO:0032729Positive regulation of interferon-gamma productionISSbiological_process
GO:0032755Positive regulation of interleukin-6 productionISSbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionIMPbiological_process
GO:0033209Tumor necrosis factor-mediated signaling pathwayIDAbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0042104Positive regulation of activated T cell proliferationISSbiological_process
GO:0042771Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIMPbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043065Positive regulation of apoptotic processIDAbiological_process
GO:0043124Negative regulation of I-kappaB kinase/NF-kappaB signalingIDAbiological_process
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0044351MacropinocytosisISSbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046330Positive regulation of JNK cascadeIMPbiological_process
GO:0050718Positive regulation of interleukin-1 beta secretionIDAbiological_process
GO:0050766Positive regulation of phagocytosisISSbiological_process
GO:0050829Defense response to Gram-negative bacteriumIMPbiological_process
GO:0050870Positive regulation of T cell activationIMPbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0051607Defense response to virusIDAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0071222Cellular response to lipopolysaccharideIDAbiological_process
GO:0071347Cellular response to interleukin-1IDAbiological_process
GO:0071356Cellular response to tumor necrosis factorIDAbiological_process
GO:0071901Negative regulation of protein serine/threonine kinase activityIDAbiological_process
GO:0072332Intrinsic apoptotic signaling pathway by p53 class mediatorIMPbiological_process
GO:0072558NLRP1 inflammasome complexIDAcellular_component
GO:0072559NLRP3 inflammasome complexIDAcellular_component
GO:0090197Positive regulation of chemokine secretionIMPbiological_process
GO:0090200Positive regulation of release of cytochrome c from mitochondriaIDAbiological_process
GO:0097169AIM2 inflammasome complexIDAcellular_component
GO:2000406Positive regulation of T cell migrationISSbiological_process
GO:2000484Positive regulation of interleukin-8 secretionIMPbiological_process
GO:2000778Positive regulation of interleukin-6 secretionIMPbiological_process
GO:2001056Positive regulation of cysteine-type endopeptidase activityIDAbiological_process
GO:2001181Positive regulation of interleukin-10 secretionIMPbiological_process
GO:2001238Positive regulation of extrinsic apoptotic signaling pathwayIDAbiological_process
GO:2001242Regulation of intrinsic apoptotic signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99703639680.00089724550.99999024730.0566338902

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4605406957
GSE13712_SHEARDown-0.7929925679
GSE13712_STATICDown-0.1393852853
GSE19018Down-0.2457174391
GSE19899_A1Down-0.7920775894
GSE19899_A2Down-0.8798186727
PubMed_21979375_A1Down-1.3397534868
PubMed_21979375_A2Down-1.4252013340
GSE35957Down-1.0315047232
GSE36640Down-0.5480787873
GSE54402Down-0.7084169370
GSE9593Down-0.7838022009
GSE43922Down-0.6871830011
GSE24585Down-0.0148074900
GSE37065Up0.2914682334
GSE28863_A1Down-0.2717324408
GSE28863_A2Down-0.4824468373
GSE28863_A3Down-0.2109948949
GSE28863_A4Up0.0769228718
GSE48662Down-0.6667212218

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022399MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.