HCSGD entry for DROSHA
1. General information
| Official gene symbol | DROSHA |
|---|---|
| Entrez ID | 29102 |
| Gene full name | drosha, ribonuclease type III |
| Other gene symbols | ETOHI2 HSA242976 RANSE3L RN3 RNASE3L RNASEN |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0004525 | Ribonuclease III activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IEA | cellular_component |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010586 | MiRNA metabolic process | IEA | biological_process |
| GO:0016075 | RRNA catabolic process | IEA | biological_process |
| GO:0031054 | Pre-miRNA processing | IEA | biological_process |
| GO:0042254 | Ribosome biogenesis | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9910108507 | 0.0063465826 | 0.9999902473 | 0.1620256062 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4088207636 |
| GSE13712_SHEAR | Down | -0.5953170415 |
| GSE13712_STATIC | Down | -0.4182120600 |
| GSE19018 | Down | -0.3001490493 |
| GSE19899_A1 | Down | -1.1494536690 |
| GSE19899_A2 | Down | -0.6750208558 |
| PubMed_21979375_A1 | Down | -0.6833242220 |
| PubMed_21979375_A2 | Down | -0.7712972704 |
| GSE35957 | Down | -0.1395326634 |
| GSE36640 | Down | -0.6448614201 |
| GSE54402 | Down | -0.2611133840 |
| GSE9593 | Down | -0.2027132191 |
| GSE43922 | Down | -0.4436072354 |
| GSE24585 | Up | 0.2339709263 |
| GSE37065 | Down | -0.1268229380 |
| GSE28863_A1 | Up | 0.0978870375 |
| GSE28863_A2 | Up | 0.4242194516 |
| GSE28863_A3 | Down | -0.1791079505 |
| GSE28863_A4 | Down | -0.2909141243 |
| GSE48662 | Down | -0.2463454254 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023847 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-760 | MIMAT0004957 | MIRT036738 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-505-3p | MIMAT0002876 | MIRT041036 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30d-5p | MIMAT0000245 | MIRT047817 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT049958 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21311220 | Downregulation of Dicer or Drosha, two major enzymes in microRNA biogenesis, lowered microRNA levels, but, unexpectedly, it also reduced global translation |
| 21311220 | While a reduction in Dicer levels markedly enhanced cellular senescence, reduction of Drosha levels did not, suggesting that the Drosha/Dicer effects on translation may be independent of senescence, and further suggesting that microRNAs may directly or indirectly enhance mRNA translation in WI-38 cells |
| 21311220 | We discuss possible scenarios through which Dicer/Drosha/microRNAs could enhance translation |
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