HCSGD entry for ANPEP
1. General information
| Official gene symbol | ANPEP |
|---|---|
| Entrez ID | 290 |
| Gene full name | alanyl (membrane) aminopeptidase |
| Other gene symbols | APN CD13 GP150 LAP1 P150 PEPN |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0001618 | Virus receptor activity | IEA | molecular_function |
| GO:0002003 | Angiotensin maturation | TAS | biological_process |
| GO:0004177 | Aminopeptidase activity | IEA | molecular_function |
| GO:0004872 | Receptor activity | TAS | molecular_function |
| GO:0005765 | Lysosomal membrane | IDA | cellular_component |
| GO:0005793 | Endoplasmic reticulum-Golgi intermediate compartment | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0008237 | Metallopeptidase activity | IEA | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0009897 | External side of plasma membrane | IEA | cellular_component |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0004905817 | 0.9929656092 | 0.0623797101 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4383390903 |
| GSE13712_SHEAR | Up | 0.0970436649 |
| GSE13712_STATIC | Up | 0.2886295132 |
| GSE19018 | Down | -0.0528220243 |
| GSE19899_A1 | Up | 0.9403234535 |
| GSE19899_A2 | Up | 0.8380064585 |
| PubMed_21979375_A1 | Up | 1.1776519599 |
| PubMed_21979375_A2 | Up | 1.0848320623 |
| GSE35957 | Down | -0.1276947098 |
| GSE36640 | Up | 0.1434795131 |
| GSE54402 | Up | 1.0860298697 |
| GSE9593 | Up | 0.1172672887 |
| GSE43922 | Up | 1.1601391192 |
| GSE24585 | Up | 0.6875651457 |
| GSE37065 | Up | 0.1876608681 |
| GSE28863_A1 | Up | 1.4310310410 |
| GSE28863_A2 | Up | 1.5818465095 |
| GSE28863_A3 | Up | 0.3588767768 |
| GSE28863_A4 | Up | 0.0139594567 |
| GSE48662 | Down | -0.4993849267 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT001389 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005211 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020955 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022990 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030575 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031867 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17961760 | To further refine the procedure, we tempted to completely inhibit collagen synthesis by beta-aminopropionitrile (beta APN) added to cultures in order to obtain a negative control |
| 17961760 | Using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl 2H-tetrazolium bromide (MTT-test), it could be shown that relatively high concentrations of beta APN are tolerated by the cells |
| 17961760 | It appeared, however, that even the highest concentration of beta APN (1mM) still tolerated by the fibroblasts did not completely inhibit collagen synthesis |
| 17961760 | At low concentrations, beta APN even stimulated cell-proliferation |
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