HCSGD entry for RGCC

1. General information

Official gene symbolRGCC
Entrez ID28984
Gene full nameregulator of cell cycle
Other gene symbolsC13orf15 RGC-32 RGC32 bA157L14.2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001100Negative regulation of exit from mitosisIDAbiological_process
GO:0001937Negative regulation of endothelial cell proliferationIDAbiological_process
GO:0003331Positive regulation of extracellular matrix constituent secretionIDAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0006956Complement activationIMPbiological_process
GO:0008285Negative regulation of cell proliferationIMPbiological_process
GO:0010718Positive regulation of epithelial to mesenchymal transitionIDA IMPbiological_process
GO:0016525Negative regulation of angiogenesisIDAbiological_process
GO:0019901Protein kinase bindingIPI ISSmolecular_function
GO:0030295Protein kinase activator activityIDAmolecular_function
GO:0031659Positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycleIDAbiological_process
GO:0032967Positive regulation of collagen biosynthetic processIDAbiological_process
GO:0043537Negative regulation of blood vessel endothelial cell migrationIDAbiological_process
GO:0045840Positive regulation of mitosisIMPbiological_process
GO:0050710Negative regulation of cytokine secretionIMPbiological_process
GO:0050715Positive regulation of cytokine secretionIMPbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIMPbiological_process
GO:0051496Positive regulation of stress fiber assemblyIDAbiological_process
GO:0070412R-SMAD bindingIPImolecular_function
GO:0071158Positive regulation of cell cycle arrestIDAbiological_process
GO:0071456Cellular response to hypoxiaIMPbiological_process
GO:0071850Mitotic cell cycle arrestIDAbiological_process
GO:0072537Fibroblast activationISSbiological_process
GO:0090272Negative regulation of fibroblast growth factor productionIDAbiological_process
GO:1901313Positive regulation of gene expression involved in extracellular matrix organizationIDAbiological_process
GO:1901991Negative regulation of mitotic cell cycle phase transitionIDAbiological_process
GO:2000048Negative regulation of cell-cell adhesion mediated by cadherinIDAbiological_process
GO:2000353Positive regulation of endothelial cell apoptotic processIDAbiological_process
GO:2000573Positive regulation of DNA biosynthetic processISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01140299760.23690607120.27015148510.9366989184

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0225723479
GSE13712_SHEARUp0.0379677769
GSE13712_STATICDown-0.3666910686
GSE19018Down-0.4227089935
GSE19899_A1Down-0.0054835915
GSE19899_A2Down-0.5915302153
PubMed_21979375_A1Up1.0666667391
PubMed_21979375_A2Up1.7431207892
GSE35957Up0.3835650455
GSE36640Up1.1112451632
GSE54402Down-3.7064912812
GSE9593Up1.2625921916
GSE43922Up1.1412884105
GSE24585Up0.2148346851
GSE37065Up0.3863939815
GSE28863_A1Up0.0895270541
GSE28863_A2Up0.4508653361
GSE28863_A3Up0.0216595071
GSE28863_A4Up0.0058482079
GSE48662Up0.2494076060

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017536MicroarrayFunctional MTI (Weak)18185580
hsa-miR-26b-5pMIMAT0000083MIRT029225MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.