HCSGD entry for GRN
1. General information
| Official gene symbol | GRN |
|---|---|
| Entrez ID | 2896 |
| Gene full name | granulin |
| Other gene symbols | CLN11 GEP GP88 PCDGF PEPI PGRN |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001835 | Blastocyst hatching | IEA | biological_process |
| GO:0005125 | Cytokine activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0007566 | Embryo implantation | IEA | biological_process |
| GO:0008083 | Growth factor activity | TAS | molecular_function |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0050679 | Positive regulation of epithelial cell proliferation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0003058053 | 0.9943498993 | 0.0467970930 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.7860556669 |
| GSE13712_SHEAR | Down | -0.0540459836 |
| GSE13712_STATIC | Up | 0.0588703755 |
| GSE19018 | Up | 0.8226775545 |
| GSE19899_A1 | Up | 0.4126286267 |
| GSE19899_A2 | Up | 1.4494257305 |
| PubMed_21979375_A1 | Up | 1.4009261079 |
| PubMed_21979375_A2 | Up | 2.1325468392 |
| GSE35957 | Up | 0.2416841572 |
| GSE36640 | Up | 1.8704559478 |
| GSE54402 | Down | -0.4597742890 |
| GSE9593 | Up | 1.2692401606 |
| GSE43922 | Up | 0.4061622665 |
| GSE24585 | Up | 0.7548738601 |
| GSE37065 | Up | 0.1993980041 |
| GSE28863_A1 | Up | 0.4801202445 |
| GSE28863_A2 | Up | 1.0599621655 |
| GSE28863_A3 | Up | 0.4142036725 |
| GSE28863_A4 | Down | -0.0915773348 |
| GSE48662 | Down | -0.0156591399 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-659-3p | MIMAT0003337 | MIRT000034 | Luciferase reporter assay//Western blot | Functional MTI | 18723524 |
| hsa-miR-107 | MIMAT0000104 | MIRT004761 | Microarray//Western blot | Functional MTI | 20884628 |
| hsa-miR-107 | MIMAT0000104 | MIRT004761 | Reporter assay;Western blot;Microarray | Functional MTI | 20489155 |
| hsa-miR-29b-3p | MIMAT0000100 | MIRT005486 | ELISA//Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay;Western blot;Other | Functional MTI | 20479936 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021404 | Reporter assay | Non-Functional MTI | 20479936 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-659-3p | MIMAT0003337 | 1 | hsa-miR-659 | {Western blot} | {overexpression by miRNA mimics tranfection} | 18723524 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26600492 | Effect of progranulin (PGRN) on the proliferation and senescence of cervical cancer cells |
| 26600492 | We investigated the effect of progranulin (PGRN) expression on the proliferation and senescence of cervical cancer cells |
| 26600492 | PGRN small interfering RNA (siRNA) was introduced into the SiHa and HeLa cell lines of human cervical carcinoma using liposome-mediated transfection |
| 26600492 | The expression levels of PGRN in each cell line after transfection of PGRN siRNA were detected by reverse transcription-polymerase chain reaction (RT-PCR) |
| 26600492 | The RT-PCR assay showed that the expression of PGRN in all of the cell lines transfected with PGRN siRNA markedly decreased |
| 26600492 | In the clone-forming test, compared with the control group, the colony-forming ability in all cell lines decreased significantly after transfection with PGRN siRNA |
| 26600492 | The beta-galactosidase-staining experiments showed that the phenomenon of cell aging in the PGRN interference group was more obvious than in the control group |
| 26600492 | This suggests that PGRN can promote the proliferation of the cervical cancer cell line; proliferation of cervical cancer cells is achieved by inhibiting their senescence |
| 22733568 | Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice |
| 22733568 | Loss-of-function mutations in progranulin (GRN) are associated with frontotemporal lobar degeneration with intraneuronal ubiquitinated protein accumulations composed primarily of hyperphosphorylated TDP-43 (FTLD-TDP) |
| 22733568 | The mechanism by which GRN deficiency causes TDP-43 pathology or neurodegeneration remains elusive |
| 22733568 | To explore the role of GRN in vivo, we established Grn knockout mice using a targeted genomic recombination approach and Cre-LoxP technology |
| 22733568 | Constitutive Grn homozygous knockout (Grn(-/-) ) mice were born in an expected Mendelian pattern of inheritance and showed no phenotypic alterations compared to heterozygous (Grn(+/-) ) or wild-type (Wt) littermates until 10 months of age |
| 22733568 | From then, Grn(-/-) mice showed reduced survival accompanied by significantly increased gliosis and ubiquitin-positive accumulations in the cortex, hippocampus, and subcortical regions |
| 22733568 | Although phosphorylated TDP-43 could not be detected in the ubiquitinated inclusions, elevated levels of hyperphosphorylated full-length TDP-43 were recovered from detergent-insoluble brain fractions of Grn(-/-) mice |
| 22733568 | Grn(-/-) mice also showed degenerative liver changes and cathepsin D-positive foamy histiocytes within sinusoids, suggesting widespread defects in lysosomal turnover |
| 22733568 | An increase in insulin-like growth factor (IGF)-1 was observed in Grn(-/-) brains, and increased IGF-1 signalling has been associated with decreased longevity |
| 22733568 | Our data suggest that progranulin deficiency in mice leads to reduced survival in adulthood and increased cellular ageing accompanied by hyperphosphorylation of TDP-43, and recapitulates key aspects of FTLD-TDP neuropathology |
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