HCSGD entry for TRIB2
1. General information
| Official gene symbol | TRIB2 |
|---|---|
| Entrez ID | 28951 |
| Gene full name | tribbles homolog 2 (Drosophila) |
| Other gene symbols | C5FW GS3955 TRB2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | ISS | molecular_function |
| GO:0004672 | Protein kinase activity | IEA ISS | molecular_function |
| GO:0004860 | Protein kinase inhibitor activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA ISS | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0006468 | Protein phosphorylation | ISS | biological_process |
| GO:0006469 | Negative regulation of protein kinase activity | NAS | biological_process |
| GO:0008134 | Transcription factor binding | IEA ISS | molecular_function |
| GO:0031625 | Ubiquitin protein ligase binding | IEA ISS | molecular_function |
| GO:0032436 | Positive regulation of proteasomal ubiquitin-dependent protein catabolic process | IEA ISS | biological_process |
| GO:0043405 | Regulation of MAP kinase activity | ISS | biological_process |
| GO:0045081 | Negative regulation of interleukin-10 biosynthetic process | IMP | biological_process |
| GO:0045599 | Negative regulation of fat cell differentiation | IEA ISS | biological_process |
| GO:0055106 | Ubiquitin-protein ligase regulator activity | IEA ISS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7650107139 | 0.0034957866 | 0.9999902473 | 0.1202554688 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2930766099 |
| GSE13712_SHEAR | Down | -1.7199517689 |
| GSE13712_STATIC | Down | -0.5579060346 |
| GSE19018 | Down | -0.1047687120 |
| GSE19899_A1 | Down | -0.4139385220 |
| GSE19899_A2 | Down | -1.3479874654 |
| PubMed_21979375_A1 | Down | -1.1585572464 |
| PubMed_21979375_A2 | Down | -0.2226557057 |
| GSE35957 | Down | -0.0616281481 |
| GSE36640 | Up | 1.3025580597 |
| GSE54402 | Up | 0.0083445761 |
| GSE9593 | Up | 0.3394982096 |
| GSE43922 | Down | -0.1414737697 |
| GSE24585 | Down | -1.5847158776 |
| GSE37065 | Down | -0.4249746440 |
| GSE28863_A1 | Down | -0.3760372193 |
| GSE28863_A2 | Up | 0.2942703762 |
| GSE28863_A3 | Down | -0.1137946410 |
| GSE28863_A4 | Down | -0.0744630258 |
| GSE48662 | Up | 0.8830200835 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-511-5p | MIMAT0002808 | MIRT007037 | GFP reporter assay | Functional MTI | 23071539 |
| hsa-miR-1297 | MIMAT0005886 | MIRT007038 | GFP reporter assay | Functional MTI | 23071539 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044275 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
