HCSGD entry for GRB10
1. General information
| Official gene symbol | GRB10 |
|---|---|
| Entrez ID | 2887 |
| Gene full name | growth factor receptor-bound protein 10 |
| Other gene symbols | GRB-IR Grb-10 IRBP MEG1 RSS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005070 | SH3/SH2 adaptor activity | IEA | molecular_function |
| GO:0005158 | Insulin receptor binding | ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | ISS TAS | biological_process |
| GO:0030178 | Negative regulation of Wnt signaling pathway | IDA | biological_process |
| GO:0030949 | Positive regulation of vascular endothelial growth factor receptor signaling pathway | IDA | biological_process |
| GO:0032868 | Response to insulin | ISS | biological_process |
| GO:0042326 | Negative regulation of phosphorylation | IEA | biological_process |
| GO:0042327 | Positive regulation of phosphorylation | IEA ISS | biological_process |
| GO:0045719 | Negative regulation of glycogen biosynthetic process | IEA ISS | biological_process |
| GO:0046325 | Negative regulation of glucose import | ISS | biological_process |
| GO:0046627 | Negative regulation of insulin receptor signaling pathway | ISS | biological_process |
| GO:0048009 | Insulin-like growth factor receptor signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0147155199 | 0.6084531021 | 0.3023631538 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1706293361 |
| GSE13712_SHEAR | Up | 0.0421247647 |
| GSE13712_STATIC | Down | -0.8747590270 |
| GSE19018 | Up | 0.0126325570 |
| GSE19899_A1 | Up | 0.4121261717 |
| GSE19899_A2 | Up | 1.0421975504 |
| PubMed_21979375_A1 | Up | 1.7414979038 |
| PubMed_21979375_A2 | Up | 1.1896777164 |
| GSE35957 | Down | -0.7525093738 |
| GSE36640 | Up | 0.1515083871 |
| GSE54402 | Up | 1.0468943847 |
| GSE9593 | Up | 0.3030162323 |
| GSE43922 | Up | 1.1668833494 |
| GSE24585 | Down | -0.4877952246 |
| GSE37065 | Up | 0.1589295400 |
| GSE28863_A1 | Up | 0.0882319652 |
| GSE28863_A2 | Up | 0.1057796112 |
| GSE28863_A3 | Down | -0.0655766188 |
| GSE28863_A4 | Down | -0.2685718012 |
| GSE48662 | Up | 0.0834632277 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT019136 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020299 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037307 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046714 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
