HCSGD entry for GPX7
1. General information
| Official gene symbol | GPX7 |
|---|---|
| Entrez ID | 2882 |
| Gene full name | glutathione peroxidase 7 |
| Other gene symbols | CL683 GPX6 GPx-7 GSHPx-7 NPGPx |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004602 | Glutathione peroxidase activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0006979 | Response to oxidative stress | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9776277649 | 0.0028724972 | 0.9999902473 | 0.1073058074 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2125900001 |
| GSE13712_SHEAR | Down | -0.0783750536 |
| GSE13712_STATIC | Up | 0.1341757155 |
| GSE19018 | Down | -0.6531586026 |
| GSE19899_A1 | Down | -0.2883098773 |
| GSE19899_A2 | Down | -1.2519609361 |
| PubMed_21979375_A1 | Up | 0.1322616708 |
| PubMed_21979375_A2 | Down | -1.3523129246 |
| GSE35957 | Down | -0.8905754073 |
| GSE36640 | Down | -0.8648176118 |
| GSE54402 | Down | -0.5051351981 |
| GSE9593 | Down | -1.2673492575 |
| GSE43922 | Down | -0.8768500673 |
| GSE24585 | Up | 0.0740511164 |
| GSE37065 | Down | -0.1933273115 |
| GSE28863_A1 | Down | -0.1138119389 |
| GSE28863_A2 | Down | -0.0974394219 |
| GSE28863_A3 | Up | 0.1615785470 |
| GSE28863_A4 | Down | -0.1978397256 |
| GSE48662 | Down | -0.2521036651 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Glutathione | DB00143 | NUTR00029 | EXPT01650 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT005045 | Microarray | Functional MTI (Weak) | 17699775 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022803 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23580780 | Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma |
| 23580780 | OBJECTIVE: To investigate the potential tumour suppressor functions of glutathione peroxidase 7 (GPX7) and examine the interplay between epigenetic and genetic events in regulating its expression in oesophageal adenocarcinomas (OAC) |
| 23580780 | DESIGN: In vitro and in vivo cell models were developed to investigate the biological and molecular functions of GPX7 in OAC |
| 23580780 | RESULTS: Reconstitution of GPX7 in OAC cell lines, OE33 and FLO-1, significantly suppressed growth as shown by the growth curve, colony formation and EdU proliferation assays |
| 23580780 | Pyrosequencing of the GPX7 promoter region (-162 to +138) demonstrated location-specific hypermethylation between +13 and +64 in OAC (69%, 54/78) |
| 23580780 | This was significantly associated with the downregulation of GPX7 (p<0 |
| 23580780 | Neither mutations in the coding exons of GPX7 nor DNA copy number losses were frequently present in the OAC examined (<5%) |
| 23580780 | CONCLUSIONS: Our data suggest that GPX7 possesses tumour suppressor functions in OAC and is silenced by location-specific promoter DNA methylation |
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