HCSGD entry for GPX4
1. General information
| Official gene symbol | GPX4 |
|---|---|
| Entrez ID | 2879 |
| Gene full name | glutathione peroxidase 4 |
| Other gene symbols | GPx-4 GSHPx-4 MCSP PHGPx snGPx snPHGPx |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004602 | Glutathione peroxidase activity | IEA TAS | molecular_function |
| GO:0005635 | Nuclear envelope | IEA | cellular_component |
| GO:0005739 | Mitochondrion | TAS | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006325 | Chromatin organization | IEA | biological_process |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0006749 | Glutathione metabolic process | IEA | biological_process |
| GO:0006979 | Response to oxidative stress | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0007283 | Spermatogenesis | IEA | biological_process |
| GO:0007568 | Aging | IEA | biological_process |
| GO:0008430 | Selenium binding | IEA | molecular_function |
| GO:0019369 | Arachidonic acid metabolic process | TAS | biological_process |
| GO:0019372 | Lipoxygenase pathway | TAS | biological_process |
| GO:0032355 | Response to estradiol | IEA | biological_process |
| GO:0042744 | Hydrogen peroxide catabolic process | IEA | biological_process |
| GO:0043295 | Glutathione binding | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0047066 | Phospholipid-hydroperoxide glutathione peroxidase activity | IEA | molecular_function |
| GO:0050727 | Regulation of inflammatory response | IEA | biological_process |
| GO:0055114 | Oxidation-reduction process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6719209225 | 0.0455960374 | 0.9999902473 | 0.4005978993 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6963589809 |
| GSE13712_SHEAR | Down | -0.0303151692 |
| GSE13712_STATIC | Down | -0.3720934218 |
| GSE19018 | Down | -0.1737777269 |
| GSE19899_A1 | Down | -1.0467411578 |
| GSE19899_A2 | Down | -0.6607553016 |
| PubMed_21979375_A1 | Up | 0.5770792254 |
| PubMed_21979375_A2 | Down | -0.1562578255 |
| GSE35957 | Down | -0.2866422717 |
| GSE36640 | Down | -0.7422111367 |
| GSE54402 | Down | -0.2769953982 |
| GSE9593 | Up | 0.3649907793 |
| GSE43922 | Down | -0.4062758068 |
| GSE24585 | Up | 0.3857711138 |
| GSE37065 | Down | -0.1551405276 |
| GSE28863_A1 | Up | 0.1559993792 |
| GSE28863_A2 | Down | -0.2621390904 |
| GSE28863_A3 | Down | -0.3639699672 |
| GSE28863_A4 | Up | 0.1175083957 |
| GSE48662 | Up | 0.1662321060 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Glutathione | DB00143 | NUTR00029 | EXPT01650 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029349 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT046107 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
