HCSGD entry for GPX1

1. General information

Official gene symbolGPX1
Entrez ID2876
Gene full nameglutathione peroxidase 1
Other gene symbolsGPXD GSHPX1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001659Temperature homeostasisIEAbiological_process
GO:0001885Endothelial cell developmentIEAbiological_process
GO:0002862Negative regulation of inflammatory response to antigenic stimulusIEAbiological_process
GO:0004602Glutathione peroxidase activityIDA TASmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006144Purine nucleobase metabolic processTASbiological_process
GO:0006195Purine nucleotide catabolic processTASbiological_process
GO:0006641Triglyceride metabolic processIEAbiological_process
GO:0006749Glutathione metabolic processIDAbiological_process
GO:0006982Response to lipid hydroperoxideIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0007605Sensory perception of soundIEAbiological_process
GO:0008430Selenium bindingIEAmolecular_function
GO:0008631Intrinsic apoptotic signaling pathway in response to oxidative stressIEAbiological_process
GO:0009410Response to xenobiotic stimulusIEAbiological_process
GO:0009609Response to symbiotic bacteriumIEAbiological_process
GO:0009636Response to toxic substanceIEAbiological_process
GO:0009650UV protectionIMPbiological_process
GO:0009749Response to glucoseIEAbiological_process
GO:0010269Response to selenium ionIMPbiological_process
GO:0010332Response to gamma radiationIEAbiological_process
GO:0017124SH3 domain bindingIPImolecular_function
GO:0018158Protein oxidationIEAbiological_process
GO:0019369Arachidonic acid metabolic processTASbiological_process
GO:0019372Lipoxygenase pathwayTASbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0033599Regulation of mammary gland epithelial cell proliferationIMPbiological_process
GO:0035094Response to nicotineIEAbiological_process
GO:0040029Regulation of gene expression, epigeneticIDAbiological_process
GO:0042311VasodilationIEAbiological_process
GO:0042542Response to hydrogen peroxideIMPbiological_process
GO:0042744Hydrogen peroxide catabolic processIDAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIMPbiological_process
GO:0043295Glutathione bindingIEAmolecular_function
GO:0043403Skeletal muscle tissue regenerationIEAbiological_process
GO:0043523Regulation of neuron apoptotic processIEAbiological_process
GO:0043534Blood vessel endothelial cell migrationIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045444Fat cell differentiationIEAbiological_process
GO:0045454Cell redox homeostasisIDAbiological_process
GO:0047066Phospholipid-hydroperoxide glutathione peroxidase activityIEAmolecular_function
GO:0048741Skeletal muscle fiber developmentIEAbiological_process
GO:0051450Myoblast proliferationIEAbiological_process
GO:0051593Response to folic acidIEAbiological_process
GO:0051702Interaction with symbiontIEAbiological_process
GO:0051897Positive regulation of protein kinase B signalingIEAbiological_process
GO:0055086Nucleobase-containing small molecule metabolic processTASbiological_process
GO:0060047Heart contractionIMPbiological_process
GO:0060055Angiogenesis involved in wound healingIEAbiological_process
GO:0061136Regulation of proteasomal protein catabolic processIDAbiological_process
GO:0090201Negative regulation of release of cytochrome c from mitochondriaIMPbiological_process
GO:1902042Negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsIMPbiological_process
GO:1902176Negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stressIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04316271420.89934158660.46238738301.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.7013834339
GSE13712_SHEARUp0.3264240107
GSE13712_STATICDown-0.0147336431
GSE19018Up0.1172375539
GSE19899_A1Up0.0480827573
GSE19899_A2Up0.2666554759
PubMed_21979375_A1Up1.0097478556
PubMed_21979375_A2Up0.2104060382
GSE35957Down-0.1095804481
GSE36640Up0.6576178131
GSE54402Up0.0813798514
GSE9593Down-0.0917713998
GSE43922Up0.0382041027
GSE24585Up0.0783108539
GSE37065Down-0.1720166021
GSE28863_A1Down-0.0157505551
GSE28863_A2Down-0.2986062022
GSE28863_A3Up0.4646752326
GSE28863_A4Up0.1860634721
GSE48662Up0.2634910838

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

GlutathioneDB00143 NUTR00029 | EXPT01650

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-92b-3pMIMAT0003218MIRT040633CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 8 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26696133The levels of some antioxidant enzymes, such as catalase, peroxiredoxin II and glutathione peroxidase I, were transiently induced by PPKO treatment
25186470Knockdown of FOXO1 and FOXO1+3 resulted in significant reductions in levels of glutathione peroxidase 1 (GPX-1), catalase, light chain 3 (LC3), Beclin1, and sirtuin 1 (SIRT-1) proteins following treatment with tBHP
25186470In contrast, the constitutive active form of FOXO3 increased cell viability while inducing GPX-1, Beclin1, and LC3 in response to tBHP
23261989IGF-1 did not increase GPX1 mRNA levels but increased GPX1 protein levels by 2
232619896-fold at 24h, and altered selenocysteine-incorporation complex formation on GPX1 mRNA
23261989In conclusion, IGF-1 upregulates GPX1 expression in hAECs via a translational mechanism, which may play an important role in the ability of IGF-1 to reduce endothelial cell oxidative stress and premature senescence
21562236The expression of antioxidant defense genes, such as glutathione peroxidase-1, Cu/Zn superoxide dismutase (Sod1), paraoxonase enzymes (Pon1, Pon2, and Pon3), were significantly lower in the liver of HF/C pups than in C/C pups
16189290Thus major antioxidants, MnSOD, glutathione peroxidase I, and glutathione reductase, were also evaluated
14732290Fibroblasts derived from Gpx1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell death
14732290Our previous data highlight the importance of antioxidant enzymes, superoxide dismutase 1 (Sod1) and glutathione peroxidase 1 (Gpx1), in regulating this process
14732290In this study, we test this notion in fibroblasts derived from Gpx1 null mutant mice (Gpx1-/-) that have elevated H2O2 as a consequence of the lack of its removal by Gpx1
14732290Gpx1-/- fibroblasts also demonstrate a dose-dependent susceptibility to H2O2-induced apoptosis
14732290Our findings suggest that Gpx1 is protective against both ROS-mediated senescence-like changes and oxidant-mediated cell death
8824885O2-to H2O2) to glutathione peroxidase activity (Gpx1 catalyses H2O2 conversion to H2O) on cell growth and development
8824885Furthermore, fibroblasts established from individuals with Down syndrome have an increase in the ratio of Sod1 to Gpx1 activity compared with corresponding controls and senesce earlier
7492966This is based on our observation that an altered Cu/Zn-superoxide dismutase (Sod1)/(Gpx1 plus Cat) ratio exists in the brain of aging mice and that this correlates with increased lipid damage
7492966We also examine the Sod1 to Gpx1 ratio in Down syndrome tissue and show that all organs have an altered ratio
Entries Per Page
Displaying Page of