HCSGD entry for GPS1
1. General information
| Official gene symbol | GPS1 |
|---|---|
| Entrez ID | 2873 |
| Gene full name | G protein pathway suppressor 1 |
| Other gene symbols | COPS1 CSN1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000188 | Inactivation of MAPK activity | TAS | biological_process |
| GO:0005095 | GTPase inhibitor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0007049 | Cell cycle | TAS | biological_process |
| GO:0007254 | JNK cascade | TAS | biological_process |
| GO:0008180 | COP9 signalosome | IDA IEA | cellular_component |
| GO:0010388 | Cullin deneddylation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0344625812 | 0.9267606132 | 0.4260995303 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4713404962 |
| GSE13712_SHEAR | Up | 0.3367096797 |
| GSE13712_STATIC | Up | 0.4545124888 |
| GSE19018 | Up | 0.1294469715 |
| GSE19899_A1 | Down | -0.2806573012 |
| GSE19899_A2 | Up | 0.2905396722 |
| PubMed_21979375_A1 | Up | 1.7246615865 |
| PubMed_21979375_A2 | Up | 1.0075392253 |
| GSE35957 | Down | -0.2375151632 |
| GSE36640 | Up | 0.4392641692 |
| GSE54402 | Up | 0.2261691684 |
| GSE9593 | Down | -0.1300935885 |
| GSE43922 | Up | 0.1237199151 |
| GSE24585 | Up | 0.2109676510 |
| GSE37065 | Down | -0.1615068774 |
| GSE28863_A1 | Up | 0.0664960436 |
| GSE28863_A2 | Down | -0.0345707830 |
| GSE28863_A3 | Down | -0.3334447824 |
| GSE28863_A4 | Up | 0.0458590622 |
| GSE48662 | Up | 0.3108977928 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7i-5p | MIMAT0000415 | MIRT024116 | Western blot | Functional MTI | 21530537 |
| hsa-let-7f-5p | MIMAT0000067 | MIRT032090 | Western blot | Functional MTI | 21530537 |
| hsa-let-7e-3p | MIMAT0004485 | MIRT032096 | Western blot | Functional MTI | 21530537 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT032191 | Western blot | Functional MTI | 21530537 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042619 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196b-5p | MIMAT0001080 | MIRT042663 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048796 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
