HCSGD entry for GRK5
1. General information
| Official gene symbol | GRK5 |
|---|---|
| Entrez ID | 2869 |
| Gene full name | G protein-coupled receptor kinase 5 |
| Other gene symbols | GPRK5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0004703 | G-protein coupled receptor kinase activity | IEA | molecular_function |
| GO:0005080 | Protein kinase C binding | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005543 | Phospholipid binding | TAS | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0007188 | Adenylate cyclase-modulating G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0007217 | Tachykinin receptor signaling pathway | IDA | biological_process |
| GO:0008277 | Regulation of G-protein coupled receptor protein signaling pathway | TAS | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0038032 | Termination of G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IDA | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6068692527 | 0.1574179211 | 0.9999902473 | 0.7665859574 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0294140147 |
| GSE13712_SHEAR | Down | -0.5667213828 |
| GSE13712_STATIC | Down | -0.2365420485 |
| GSE19018 | Up | 0.0708304761 |
| GSE19899_A1 | Down | -0.2520033214 |
| GSE19899_A2 | Down | -0.2835240457 |
| PubMed_21979375_A1 | Down | -0.0668858118 |
| PubMed_21979375_A2 | Up | 0.0631963354 |
| GSE35957 | Down | -0.4383846911 |
| GSE36640 | Down | -0.0930287711 |
| GSE54402 | Down | -0.4235203536 |
| GSE9593 | Up | 0.1893132474 |
| GSE43922 | Down | -0.2082082285 |
| GSE24585 | Down | -0.2610113730 |
| GSE37065 | Up | 0.3147515619 |
| GSE28863_A1 | Up | 0.4497385636 |
| GSE28863_A2 | Up | 0.4060208303 |
| GSE28863_A3 | Up | 0.0961138312 |
| GSE28863_A4 | Up | 0.2070173292 |
| GSE48662 | Up | 0.0469090786 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-941 | MIMAT0004984 | MIRT036566 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
