HCSGD entry for PTRF
1. General information
| Official gene symbol | PTRF |
|---|---|
| Entrez ID | 284119 |
| Gene full name | polymerase I and transcript release factor |
| Other gene symbols | CAVIN CAVIN1 CGL4 cavin-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005901 | Caveola | IDA | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006360 | Transcription from RNA polymerase I promoter | TAS | biological_process |
| GO:0006361 | Transcription initiation from RNA polymerase I promoter | IDA | biological_process |
| GO:0006363 | Termination of RNA polymerase I transcription | IDA TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0042134 | RRNA primary transcript binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4475130352 | 0.0084869952 | 0.9999902473 | 0.1841600989 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.7419809144 |
| GSE13712_SHEAR | Down | -0.2158250180 |
| GSE13712_STATIC | Down | -0.2594405395 |
| GSE19018 | Down | -0.1010584096 |
| GSE19899_A1 | Down | -1.3924217161 |
| GSE19899_A2 | Down | -0.8404625505 |
| PubMed_21979375_A1 | Down | -1.7480518693 |
| PubMed_21979375_A2 | Down | -1.5167519677 |
| GSE35957 | Up | 0.0397986468 |
| GSE36640 | Up | 0.1782825365 |
| GSE54402 | Down | -0.7248885125 |
| GSE9593 | Up | 0.3923241923 |
| GSE43922 | Down | -0.5994284757 |
| GSE24585 | Up | 0.2278367596 |
| GSE37065 | Down | -0.8122713386 |
| GSE28863_A1 | Up | 0.7699682425 |
| GSE28863_A2 | Up | 0.3693051699 |
| GSE28863_A3 | Up | 0.4813751299 |
| GSE28863_A4 | Up | 0.2182330074 |
| GSE48662 | Down | -0.1651004156 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT023054 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-342-3p | MIMAT0000753 | MIRT043709 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25407919 | Senescent EC induced by either the overexpression of ARHGAP18/SENEX or by H(2)O(2) showed significantly increased numbers of caveolae and associated proteins Caveolin-1, cavin-1 and cavin-2 |
| 24812087 | Polymerase I and transcript release factor (PTRF) regulates adipocyte differentiation and determines adipose tissue expandability |
| 24812087 | Using proteomics, we compared subcutaneous adipose tissues from mice in these groups and found that the expression of PTRF (polymerase I and transcript release factor) associated selectively with their glucose tolerance status |
| 24812087 | Lentiviral and pharmacologically overexpressed PTRF, whose function is critical for caveola formation, compromised adipocyte differentiation of cultured 3T3-L1cells |
| 24812087 | In human adipose tissue, PTRF mRNA levels positively correlated with markers of lipolysis and cellular senescence |
| 24812087 | Furthermore, a negative relationship between telomere length and PTRF mRNA levels was observed in human subcutaneous fat |
| 24812087 | PTRF is associated with limited adipose tissue expansion underpinning the key role of caveolae in adipocyte regulation |
| 24812087 | Furthermore, PTRF may be a suitable adipocyte marker for predicting pathological obesity and inform clinical management |
| 24471649 | Increased polymerase I and transcript release factor (Cavin-1) expression attenuates platelet-derived growth factor receptor signalling in senescent human fibroblasts |
| 24471649 | Previously, we showed that the essential caveolar component polymerase I and transcript release factor (PTRF) was upregulated and promoted caveolae formation in senescent cells |
| 24471649 | In addition, we found that overexpression of PTRF increased the number of caveolae and induced cellular senescence |
| 24471649 | Herein, we investigated the role of PTRF in the regulation of platelet-derived growth factor (PDGF) signalling in young and senescent cells |
| 24471649 | We first confirmed that PTRF was upregulated in senescent human fibroblasts and aged mouse tissues |
| 24471649 | Furthermore, our results show that PTRF interacts with PDGFRs and this interaction is increased in senescent cells |
| 24471649 | These results suggest that the unresponsiveness of senescent fibroblasts to PDGF stimulation may be due to increased levels of PTRF and the formation of caveolae, which, in turn sequester growth receptors, such as PDGFR and its signalling molecules |
| 23941874 | Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound healing in diabetes |
| 23941874 | Mechanistically, we found that diabetes-induced oxidative stress upregulated caveolin-1 (Cav-1) and PTRF expression, which in turn sequestered Mdm2 away from p53 |
| 23941874 | Intriguingly, we confirmed that the targeted depletion of Cav-1 or PTRF using siRNA- or Vivo-Morpholino antisense-based gene therapy markedly inhibited diabetes/oxidative stress-induced premature senescence and also accelerated tissue repair in this disease state |
| 21445100 | Regulation of cellular senescence by the essential caveolar component PTRF/Cavin-1 |
| 21445100 | Polymerase I and transcript release factor (PTRF, also known as Cavin-1) is an essential component in the biogenesis and function of caveolae |
| 21445100 | Here, we show that PTRF expression is increased in senescent human fibroblasts |
| 21445100 | Importantly, overexpression of PTRF induced features characteristic of cellular senescence, whereas reduced PTRF expression extended the cellular replicative lifespan |
| 21445100 | Interestingly, we found that PTRF localized primarily to the nuclei of young and quiescent WI-38 human fibroblasts, but translocated to the cytosol and plasma membrane during cellular senescence |
| 21445100 | Our data suggest that the role of PTRF in cellular senescence is dependent on its targeting to caveolae and its interaction with caveolin-1, which appeared to be regulated by the phosphorylation of PTRF |
| 21445100 | Taken together, our findings identify PTRF as a novel regulator of cellular senescence that acts through the p53/p21 and caveolar pathways |
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