HCSGD entry for ANGPT1

1. General information

Official gene symbolANGPT1
Entrez ID284
Gene full nameangiopoietin 1
Other gene symbolsAGP1 AGPT ANG1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001936Regulation of endothelial cell proliferationIDAbiological_process
GO:0002040Sprouting angiogenesisIDAbiological_process
GO:0002092Positive regulation of receptor internalizationIDAbiological_process
GO:0005102Receptor bindingIEAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005902MicrovillusIDAcellular_component
GO:0007162Negative regulation of cell adhesionIDAbiological_process
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayIEAbiological_process
GO:0007171Activation of transmembrane receptor protein tyrosine kinase activityIDAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0010595Positive regulation of endothelial cell migrationIDAbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIEAbiological_process
GO:0014842Regulation of satellite cell proliferationIDAbiological_process
GO:0030097HemopoiesisIEAbiological_process
GO:0030154Cell differentiationIEAbiological_process
GO:0030210Heparin biosynthetic processIDAbiological_process
GO:0030971Receptor tyrosine kinase bindingIPImolecular_function
GO:0031398Positive regulation of protein ubiquitinationIDAbiological_process
GO:0031589Cell-substrate adhesionIEAbiological_process
GO:0033138Positive regulation of peptidyl-serine phosphorylationIEAbiological_process
GO:0034394Protein localization to cell surfaceIDAbiological_process
GO:0043066Negative regulation of apoptotic processIDAbiological_process
GO:0043116Negative regulation of vascular permeabilityIDA IEAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0043536Positive regulation of blood vessel endothelial cell migrationIDAbiological_process
GO:0045121Membrane raftIDAcellular_component
GO:0045785Positive regulation of cell adhesionIEAbiological_process
GO:0048014Tie signaling pathwayIDAbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIDA IEAbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0050918Positive chemotaxisIDAbiological_process
GO:0051897Positive regulation of protein kinase B signalingIDAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0072012Glomerulus vasculature developmentIEA ISSbiological_process
GO:2000352Negative regulation of endothelial cell apoptotic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.71982494970.00049384140.99999024730.0411066038

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4255315948
GSE13712_SHEARUp0.0695760301
GSE13712_STATICDown-0.0733594627
GSE19018Down-0.5445126063
GSE19899_A1Down-0.8572224009
GSE19899_A2Down-0.6286567955
PubMed_21979375_A1Down-1.0033995686
PubMed_21979375_A2Down-1.8775912042
GSE35957Up0.4326837879
GSE36640Up3.1709641167
GSE54402Down-1.8387651217
GSE9593Down-0.3360407430
GSE43922Down-0.7856301626
GSE24585Up0.1323937770
GSE37065Up0.3645925479
GSE28863_A1Down-1.1399714781
GSE28863_A2Down-1.4212084380
GSE28863_A3Down-0.4258659124
GSE28863_A4Down-0.3035692582
GSE48662Up0.2236424383

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25914755Depletion of heparan sulfate in young ECs elevated traction forces and actin filament thickness, while addition of heparan sulfate to the surface of aged ECs by treatment with angiopoietin-1 had the opposite effect
20407016Here, we show that an angiogenic factor angiopoietin-1 induces RECK expression in human umbilical vein endothelial cells (HUVEC), and RECK depletion in these cells results in defective vascular tube formation and cellular senescence
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