HCSGD entry for HECTD4
1. General information
| Official gene symbol | HECTD4 |
|---|---|
| Entrez ID | 283450 |
| Gene full name | HECT domain containing E3 ubiquitin protein ligase 4 |
| Other gene symbols | C12orf51 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004842 | Ubiquitin-protein ligase activity | IBA IEA | molecular_function |
| GO:0005634 | Nucleus | IBA | cellular_component |
| GO:0005737 | Cytoplasm | IBA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0042787 | Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IBA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0470943695 | 0.9728158277 | 0.4803680356 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0714311555 |
| GSE13712_SHEAR | Up | 0.0606058697 |
| GSE13712_STATIC | Up | 0.1434752775 |
| GSE19018 | Up | 0.0215194621 |
| GSE19899_A1 | Up | 0.0774065132 |
| GSE19899_A2 | Up | 0.0714281625 |
| PubMed_21979375_A1 | Up | 0.0082482245 |
| PubMed_21979375_A2 | Up | 0.1624046763 |
| GSE35957 | Up | 0.0678133260 |
| GSE36640 | Up | 0.2573046040 |
| GSE54402 | Up | 0.0706209807 |
| GSE9593 | Down | -0.0859282586 |
| GSE43922 | Up | 0.1247536199 |
| GSE24585 | Up | 0.2863029268 |
| GSE37065 | Up | 0.0692544659 |
| GSE28863_A1 | Up | 1.4437745457 |
| GSE28863_A2 | Up | 0.9889198483 |
| GSE28863_A3 | Up | 0.0637565614 |
| GSE28863_A4 | Down | -0.1132268876 |
| GSE48662 | Up | 0.2641161620 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016980 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038449 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045628 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
