HCSGD entry for GPI
1. General information
| Official gene symbol | GPI |
|---|---|
| Entrez ID | 2821 |
| Gene full name | glucose-6-phosphate isomerase |
| Other gene symbols | AMF GNPI NLK PGI PHI SA-36 SA36 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0004347 | Glucose-6-phosphate isomerase activity | IEA TAS | molecular_function |
| GO:0005125 | Cytokine activity | IEA | molecular_function |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006006 | Glucose metabolic process | TAS | biological_process |
| GO:0006094 | Gluconeogenesis | IEA TAS | biological_process |
| GO:0006096 | Glycolysis | IEA TAS | biological_process |
| GO:0006959 | Humoral immune response | TAS | biological_process |
| GO:0007599 | Hemostasis | TAS | biological_process |
| GO:0007611 | Learning or memory | IEA | biological_process |
| GO:0008083 | Growth factor activity | IEA | molecular_function |
| GO:0016866 | Intramolecular transferase activity | IEA | molecular_function |
| GO:0019242 | Methylglyoxal biosynthetic process | IEA | biological_process |
| GO:0043005 | Neuron projection | IEA | cellular_component |
| GO:0043154 | Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | IEA | biological_process |
| GO:0043524 | Negative regulation of neuron apoptotic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046185 | Aldehyde catabolic process | IEA | biological_process |
| GO:0048029 | Monosaccharide binding | IEA | molecular_function |
| GO:0051156 | Glucose 6-phosphate metabolic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0140221002 | 0.4483545458 | 0.2939858506 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6942367786 |
| GSE13712_SHEAR | Up | 0.1681288991 |
| GSE13712_STATIC | Up | 0.1368229786 |
| GSE19018 | Up | 0.5685221466 |
| GSE19899_A1 | Up | 0.7965518829 |
| GSE19899_A2 | Up | 0.6984422382 |
| PubMed_21979375_A1 | Up | 1.4409081510 |
| PubMed_21979375_A2 | Up | 0.9022528813 |
| GSE35957 | Down | -0.6748805059 |
| GSE36640 | Down | -1.2716268126 |
| GSE54402 | Up | 0.5851722346 |
| GSE9593 | Up | 0.0262259377 |
| GSE43922 | Up | 0.4089347701 |
| GSE24585 | Down | -0.5163590618 |
| GSE37065 | Down | -0.1652271563 |
| GSE28863_A1 | Up | 0.4144240803 |
| GSE28863_A2 | Up | 0.6936045811 |
| GSE28863_A3 | Down | -0.0070787457 |
| GSE28863_A4 | Down | -0.0444404012 |
| GSE48662 | Up | 0.0624620172 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| alpha-D-glucose 6-phosphate | DB02007 | EXPT01537 |
| 6-Phosphogluconic Acid | DB02076 | EXPT00290 |
| 5-Phospho-D-Arabinohydroxamic Acid | DB02093 | EXPT02496 |
| D-glucitol 6-phosphate | DB02548 | EXPT02834 |
| 5-Phosphoarabinonic Acid | DB03042 | EXPT02485 |
| Glucose-6-Phosphate | DB03581 | EXPT01538 |
| Erythose-4-Phosphate | DB03937 | EXPT01316 |
| Fructose-6-Phosphate | DB04493 | EXPT01383 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025482 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-1180-3p | MIMAT0005825 | MIRT035941 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036093 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036364 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-760 | MIMAT0004957 | MIRT036760 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-5p | MIMAT0004792 | MIRT037791 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038387 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-20a-3p | MIMAT0004493 | MIRT038973 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-671-5p | MIMAT0003880 | MIRT039256 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041374 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-346 | MIMAT0000773 | MIRT042705 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043341 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045497 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050947 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052162 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 12180124 | PMA stimulated Kupffer cell chemiluminescence was insensitive to human or rat beta 2 GPI |
| 12180124 | Addition of beta 2 GPI to the assay reduced chemiluminescence due to opsonization with purified IgG antibodies from systemic lupus erythematosus (SLE or syphilis (Sy) patient sera |
| 12180124 | A marked net increase in chemiluminescence is observed in the presence of Sy aPL antibodies, whereas a decrease was found when SLE aPL were added to the assay, in the presence or absence of beta 2 GPI |
| 12180124 | At a concentration of 125 micrograms/ml, beta 2 GPI significantly reduced Kupffer cell Candida albicans phagocytosis index and killing score by 50 and 10%, respectively |
| 12180124 | The present data strongly suggest that particle uptake in the presence of beta 2 GPI is coupled to an inhibition of reactive species production by liver macrophages during the respiratory burst, supporting the role of beta 2 GPI as a mediator of senescent cell removal |
| 12180124 | The present data strongly suggest that particle uptake in the presence of beta 2 GPI is coupled to an inhibition of reactive species production by liver macrophages during the respiratory burst, supporting the role of beta 2 GPI as a mediator of senescent cell removal |
| 2679892 | Cell age dependent decay of human erythrocytes glucose-6-phosphate isomerase |
| 2679892 | Glucose-6-phosphate isomerase shows a biphasic decay pattern during red blood cell aging, which is very fast during the first part of cell's life span in circulation |
| 2679892 | Electrophoretic and ion-exchange chromatographic experiments show that glucose-6-phosphate isomerase (D-glucose-6-phosphate ketol-isomerase, EC 5 |
| 2679892 | In vitro incubation of homogeneous human glucose-6-phosphate isomerase under conditions known to produce enzyme deamination does not reproduce the isozymic pattern found in erythrocytes, suggesting that one or more mechanisms other than those previously described to explain glucose-6-phosphate isomerase microheterogeneity occur in the human erythrocyte |
| 618901 | Studies on phosphoglucose isomerase from cultured human fibroblasts: absence of detectable ageing effects on the enzyme |
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