HCSGD entry for C11orf31
1. General information
| Official gene symbol | C11orf31 |
|---|---|
| Entrez ID | 280636 |
| Gene full name | chromosome 11 open reading frame 31 |
| Other gene symbols | C17orf10 SELH |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0008430 | Selenium binding | IEA | molecular_function |
| GO:0045454 | Cell redox homeostasis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7325407165 | 0.3196329965 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2140260178 |
| GSE13712_SHEAR | Down | -0.2878467291 |
| GSE13712_STATIC | Down | -0.1879283379 |
| GSE19018 | Down | -0.0465859053 |
| GSE19899_A1 | Down | -0.2241571645 |
| GSE19899_A2 | Down | -0.2662781700 |
| PubMed_21979375_A1 | Down | -0.5568708217 |
| PubMed_21979375_A2 | Down | -0.3441411162 |
| GSE35957 | Up | 0.0455187945 |
| GSE36640 | Down | -0.1985974119 |
| GSE54402 | Up | 0.2517149656 |
| GSE9593 | Up | 0.0596867574 |
| GSE43922 | Down | -0.2274241642 |
| GSE24585 | Up | 0.0824422550 |
| GSE37065 | Up | 0.0721323259 |
| GSE28863_A1 | Up | 0.1968712283 |
| GSE28863_A2 | Up | 0.2089450963 |
| GSE28863_A3 | Down | -0.2239611968 |
| GSE28863_A4 | Up | 0.2754467678 |
| GSE48662 | Up | 0.0344346111 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023591 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25336634 | Selenoprotein H (SelH), a nuclear selenoprotein, is proposed to carry redox and transactivation domains |
| 25336634 | To determine the role of SelH in genome maintenance, shRNA knockdown was employed in human normal and immortalized cell lines |
| 25336634 | SelH shRNA MRC-5 diploid fibroblasts under ambient O2 displayed a distinct profile of senescence including beta-galactosidase expression, autofluorescence, growth inhibition, and ATM pathway activation |
| 25336634 | During the course of 5-day recovery, the induction of phospho-ATM on Ser-1981 and gammaH2AX by H2O2 treatment (20 mum) subsided in scrambled shRNA but exacerbated in SelH shRNA MRC-5 cells |
| 25336634 | Results from clonogenic assays demonstrated hypersensitivity of SelH shRNA HeLa cells to paraquat and H2O2, but not to hydroxyurea, neocarzinostatin, or camptothecin |
| 25336634 | While SelH mRNA expression was induced by H2O2 treatment, SelH-GFP did not mobilize to sites of oxidative DNA damage |
| 25336634 | The glutathione level was lower in SelH shRNA than scrambled shRNA HeLa cells, and the H2O2-induced cell death was rescued in the presence of N-acetylcysteine, a glutathione precursor |
| 25336634 | Altogether, SelH protects against cellular senescence to oxidative stress through a genome maintenance pathway involving ATM and p53 |
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