HCSGD entry for GOT2

1. General information

Official gene symbolGOT2
Entrez ID2806
Gene full nameglutamic-oxaloacetic transaminase 2, mitochondrial
Other gene symbolsKAT4 KATIV mitAAT
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004069L-aspartate:2-oxoglutarate aminotransferase activityEXP IDA IEA ISSmolecular_function
GO:0005739MitochondrionIDA ISScellular_component
GO:0005743Mitochondrial inner membraneIEAcellular_component
GO:0005759Mitochondrial matrixTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005975Carbohydrate metabolic processTASbiological_process
GO:0006006Glucose metabolic processTASbiological_process
GO:0006094GluconeogenesisTASbiological_process
GO:00061032-oxoglutarate metabolic processISSbiological_process
GO:0006107Oxaloacetate metabolic processIEAbiological_process
GO:0006520Cellular amino acid metabolic processIEAbiological_process
GO:0006531Aspartate metabolic processISSbiological_process
GO:0006532Aspartate biosynthetic processIEAbiological_process
GO:0006533Aspartate catabolic processIDAbiological_process
GO:0006536Glutamate metabolic processISSbiological_process
GO:0008652Cellular amino acid biosynthetic processTASbiological_process
GO:0009058Biosynthetic processIEAbiological_process
GO:0015908Fatty acid transportIEPbiological_process
GO:0016212Kynurenine-oxoglutarate transaminase activityIEAmolecular_function
GO:00194704-hydroxyproline catabolic processTASbiological_process
GO:0019550Glutamate catabolic process to aspartateIEAbiological_process
GO:0019551Glutamate catabolic process to 2-oxoglutarateIEAbiological_process
GO:0030170Pyridoxal phosphate bindingIEAmolecular_function
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045471Response to ethanolIDAbiological_process
GO:0080130L-phenylalanine:2-oxoglutarate aminotransferase activityIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.55987584820.24810011020.99999024730.9580755575

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4957578547
GSE13712_SHEARUp0.0178567548
GSE13712_STATICUp0.0868409689
GSE19018Up0.1924361028
GSE19899_A1Down-0.2343156432
GSE19899_A2Down-0.0032745978
PubMed_21979375_A1Down-0.1470802058
PubMed_21979375_A2Up0.4897209514
GSE35957Down-0.8219067085
GSE36640Down-0.2455123548
GSE54402Up0.0370983746
GSE9593Down-0.2201059110
GSE43922Up0.0654097188
GSE24585Down-0.3637199498
GSE37065Down-0.0949202758
GSE28863_A1Up0.1162625480
GSE28863_A2Up0.0223301134
GSE28863_A3Down-0.4404881849
GSE28863_A4Up0.1288096920
GSE48662Down-0.1673644669

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Aspartic AcidDB00128 NUTR00016 | EXPT01823
L-Glutamic AcidDB00142 NUTR00027
4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-PhosphateDB02783 EXPT01857

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-93-3pMIMAT0004509MIRT038877CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041650CLASHFunctional MTI (Weak)23622248
hsa-miR-342-3pMIMAT0000753MIRT043698CLASHFunctional MTI (Weak)23622248
hsa-miR-196a-5pMIMAT0000226MIRT048281CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049202CLASHFunctional MTI (Weak)23622248
hsa-miR-17-3pMIMAT0000071MIRT050779CLASHFunctional MTI (Weak)23622248
hsa-miR-16-5pMIMAT0000069MIRT051208CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.