HCSGD entry for GNG11
1. General information
| Official gene symbol | GNG11 |
|---|---|
| Entrez ID | 2791 |
| Gene full name | guanine nucleotide binding protein (G protein), gamma 11 |
| Other gene symbols | GNGT11 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003924 | GTPase activity | TAS | molecular_function |
| GO:0004871 | Signal transducer activity | IEA | molecular_function |
| GO:0005834 | Heterotrimeric G-protein complex | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006112 | Energy reserve metabolic process | TAS | biological_process |
| GO:0006184 | GTP catabolic process | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0071377 | Cellular response to glucagon stimulus | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0074633411 | 0.0927976179 | 0.2260559264 | 0.5800820988 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.1934916088 |
| GSE13712_SHEAR | Down | -0.6403819012 |
| GSE13712_STATIC | Down | -0.6235740528 |
| GSE19018 | Up | 0.2909184342 |
| GSE19899_A1 | Up | 0.2350306379 |
| GSE19899_A2 | Up | 1.3787976521 |
| PubMed_21979375_A1 | Up | 1.8290472686 |
| PubMed_21979375_A2 | Up | 1.8918527501 |
| GSE35957 | Down | -0.5592776041 |
| GSE36640 | Up | 0.5680228316 |
| GSE54402 | Up | 0.1199221412 |
| GSE9593 | Down | -0.2604470192 |
| GSE43922 | Up | 0.7962796369 |
| GSE24585 | Up | 0.3873268821 |
| GSE37065 | Up | 0.7645706238 |
| GSE28863_A1 | Down | -1.2090289506 |
| GSE28863_A2 | Up | 0.2241923678 |
| GSE28863_A3 | Down | -1.0617831681 |
| GSE28863_A4 | Down | -0.2232525386 |
| GSE48662 | Up | 0.1754555380 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17092487 | G-protein gamma subunit GNG11 strongly regulates cellular senescence |
| 17092487 | GNG11 is a member of the gamma subunit family of heteromeric G-protein, but its function is entirely unknown |
| 17092487 | Furthermore, overexpression of GNG11 activated ERK1/2 of the MAP kinase family, but did not Ras |
| 17092487 | Collectively, these results suggest a novel senescence pathway mediated by GNG11 in response to environmental cues |
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