HCSGD entry for GNB1
1. General information
| Official gene symbol | GNB1 |
|---|---|
| Entrez ID | 2782 |
| Gene full name | guanine nucleotide binding protein (G protein), beta polypeptide 1 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001917 | Photoreceptor inner segment | IEA | cellular_component |
| GO:0003924 | GTPase activity | IDA | molecular_function |
| GO:0004871 | Signal transducer activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | ISS | cellular_component |
| GO:0005765 | Lysosomal membrane | IDA | cellular_component |
| GO:0005834 | Heterotrimeric G-protein complex | IDA IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006112 | Energy reserve metabolic process | TAS | biological_process |
| GO:0006184 | GTP catabolic process | IDA TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007191 | Adenylate cyclase-activating dopamine receptor signaling pathway | ISS | biological_process |
| GO:0007200 | Phospholipase C-activating G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0007204 | Positive regulation of cytosolic calcium ion concentration | IEA | biological_process |
| GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway | TAS | biological_process |
| GO:0007265 | Ras protein signal transduction | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0007603 | Phototransduction, visible light | TAS | biological_process |
| GO:0008283 | Cell proliferation | IEA | biological_process |
| GO:0010659 | Cardiac muscle cell apoptotic process | IEA | biological_process |
| GO:0016020 | Membrane | ISS | cellular_component |
| GO:0016056 | Rhodopsin mediated signaling pathway | TAS | biological_process |
| GO:0022400 | Regulation of rhodopsin mediated signaling pathway | TAS | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030425 | Dendrite | IEA | cellular_component |
| GO:0032403 | Protein complex binding | IDA | molecular_function |
| GO:0042622 | Photoreceptor outer segment membrane | IEA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0044297 | Cell body | IEA | cellular_component |
| GO:0050909 | Sensory perception of taste | IEA | biological_process |
| GO:0051020 | GTPase binding | IPI | molecular_function |
| GO:0060041 | Retina development in camera-type eye | IEA | biological_process |
| GO:0071377 | Cellular response to glucagon stimulus | TAS | biological_process |
| GO:0071380 | Cellular response to prostaglandin E stimulus | ISS | biological_process |
| GO:0071456 | Cellular response to hypoxia | IEA | biological_process |
| GO:0071870 | Cellular response to catecholamine stimulus | ISS | biological_process |
| GO:0097381 | Photoreceptor disc membrane | TAS | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7559760115 | 0.5513864975 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2203329164 |
| GSE13712_SHEAR | Up | 0.0084613128 |
| GSE13712_STATIC | Down | -0.0262350993 |
| GSE19018 | Up | 0.1165123032 |
| GSE19899_A1 | Down | -0.3678082787 |
| GSE19899_A2 | Up | 0.1827272887 |
| PubMed_21979375_A1 | Down | -0.1401152320 |
| PubMed_21979375_A2 | Up | 0.0044266597 |
| GSE35957 | Up | 0.0508080650 |
| GSE36640 | Up | 0.0052426345 |
| GSE54402 | Up | 0.0283850064 |
| GSE9593 | Up | 0.2009224136 |
| GSE43922 | Down | -0.0045756392 |
| GSE24585 | Up | 0.1972340997 |
| GSE37065 | Up | 0.0849279453 |
| GSE28863_A1 | Up | 0.0251189818 |
| GSE28863_A2 | Up | 0.2730166512 |
| GSE28863_A3 | Down | -0.2543222133 |
| GSE28863_A4 | Down | -0.1906673997 |
| GSE48662 | Down | -0.0155130933 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023929 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027151 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027365 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031864 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031864 | Microarray | Functional MTI (Weak) | 21199864 |
| hsa-miR-589-3p | MIMAT0003256 | MIRT040502 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106a-5p | MIMAT0000103 | MIRT048352 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT051020 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052049 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
