HCSGD entry for GLI3

1. General information

Official gene symbolGLI3
Entrez ID2737
Gene full nameGLI family zinc finger 3
Other gene symbolsACLS GCPS GLI3-190 GLI3FL PAP-A PAPA PAPA1 PAPB PHS PPDIV
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0001656Metanephros developmentIEAbiological_process
GO:0001658Branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0002052Positive regulation of neuroblast proliferationIEAbiological_process
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0005929CiliumIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0007224Smoothened signaling pathwayTASbiological_process
GO:0007411Axon guidanceIEAbiological_process
GO:0007442Hindgut morphogenesisIEAbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0008013Beta-catenin bindingIPImolecular_function
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0009952Anterior/posterior pattern specificationIEAbiological_process
GO:0009954Proximal/distal pattern formationIEAbiological_process
GO:0016485Protein processingIEAbiological_process
GO:0016592Mediator complexIDAcellular_component
GO:0016607Nuclear speckIEAcellular_component
GO:0017053Transcriptional repressor complexIEAcellular_component
GO:0021631Optic nerve morphogenesisIEAbiological_process
GO:0021775Smoothened signaling pathway involved in ventral spinal cord interneuron specificationIEAbiological_process
GO:0021776Smoothened signaling pathway involved in spinal cord motor neuron cell fate specificationIEAbiological_process
GO:0021798Forebrain dorsal/ventral pattern formationIEAbiological_process
GO:0021801Cerebral cortex radial glia guided migrationIEAbiological_process
GO:0021861Forebrain radial glial cell differentiationIEAbiological_process
GO:0022018Lateral ganglionic eminence cell proliferationIEAbiological_process
GO:0030318Melanocyte differentiationIEAbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0032332Positive regulation of chondrocyte differentiationIEAbiological_process
GO:0033077T cell differentiation in thymusISSbiological_process
GO:0035035Histone acetyltransferase bindingIPImolecular_function
GO:0035108Limb morphogenesisIMPbiological_process
GO:0042060Wound healingIEAbiological_process
GO:0042307Positive regulation of protein import into nucleusIEAbiological_process
GO:0042475Odontogenesis of dentin-containing toothIEAbiological_process
GO:0042733Embryonic digit morphogenesisIEA TASbiological_process
GO:0042826Histone deacetylase bindingIDAmolecular_function
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0043585Nose morphogenesisTASbiological_process
GO:0043586Tongue developmentIEAbiological_process
GO:0043627Response to estrogenIEAbiological_process
GO:0045060Negative thymic T cell selectionIEA ISSbiological_process
GO:0045665Negative regulation of neuron differentiationIEAbiological_process
GO:0045669Positive regulation of osteoblast differentiationIEAbiological_process
GO:0045879Negative regulation of smoothened signaling pathwayIEA ISSbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDA IEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEA IMPbiological_process
GO:0046638Positive regulation of alpha-beta T cell differentiationIEA ISSbiological_process
GO:0046639Negative regulation of alpha-beta T cell differentiationIEA ISSbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048557Embryonic digestive tract morphogenesisIEAbiological_process
GO:0048566Embryonic digestive tract developmentTASbiological_process
GO:0048589Developmental growthIEAbiological_process
GO:0048593Camera-type eye morphogenesisIEAbiological_process
GO:0048704Embryonic skeletal system morphogenesisIEAbiological_process
GO:0048709Oligodendrocyte differentiationIEAbiological_process
GO:0060021Palate developmentIEAbiological_process
GO:0060364Frontal suture morphogenesisIEAbiological_process
GO:0060366Lambdoid suture morphogenesisIEAbiological_process
GO:0060367Sagittal suture morphogenesisIEAbiological_process
GO:0060594Mammary gland specificationIEAbiological_process
GO:0060831Smoothened signaling pathway involved in dorsal/ventral neural tube patterningIEAbiological_process
GO:0060840Artery developmentIEAbiological_process
GO:0060873Anterior semicircular canal developmentIEAbiological_process
GO:0060875Lateral semicircular canal developmentIEAbiological_process
GO:0061005Cell differentiation involved in kidney developmentIEAbiological_process
GO:0070242Thymocyte apoptotic processIEA ISSbiological_process
GO:0072372Primary ciliumIEAcellular_component
GO:0090090Negative regulation of canonical Wnt signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.61394417010.08077248580.99999024730.5374147118

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0981800190
GSE13712_SHEARDown-0.4875658709
GSE13712_STATICDown-0.3410180079
GSE19018Down-0.1429177893
GSE19899_A1Down-0.0305095132
GSE19899_A2Down-0.6553343186
PubMed_21979375_A1Down-0.3529192307
PubMed_21979375_A2Up0.4562557776
GSE35957Down-0.8484404048
GSE36640Down-0.5400594944
GSE54402Up0.2780032531
GSE9593Down-0.0171906134
GSE43922Up0.0170526204
GSE24585Down-0.4211847563
GSE37065Down-0.0262083175
GSE28863_A1Up0.6717613012
GSE28863_A2Up0.4800825329
GSE28863_A3Up0.2087487285
GSE28863_A4Down-0.0277205973
GSE48662Down-0.1526905289

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1301-3pMIMAT0005797MIRT035969CLASHFunctional MTI (Weak)23622248
hsa-miR-148b-3pMIMAT0000759MIRT043590CLASHFunctional MTI (Weak)23622248
hsa-miR-93-5pMIMAT0000093MIRT048909CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25645196LiCl treatment of MB spheres down-regulated the Hh target Gli1, whereas the repressive Gli3 protein (Gli3R) was increased
15136151Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis
15136151We show Shh signaling prevents Gli3 proteolysis to generate its repressor forms (Gli3R) in the developing murine lung
15136151In Shh(-/-) or cyclopamine-treated wild-type (WT) lung, we found that Gli3R level is elevated, and this upregulation appears to contribute to defects in proliferation and differentiation observed in the Shh(-/-) mesenchyme, where Gli3 is normally expressed
15136151We found significant repression of Tbx2 and Tbx3, both linked to inhibition of cellular senescence, in Shh(-/-) and partial derepression in Shh(-/-); Gli3(-/-) lungs, while Tbx4 and Tbx5 expressions are less affected in the mutants
15136151Our findings shed light on the role of Shh signaling on Gli3 processing in lung growth and differentiation by regulating several critical genes
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