HCSGD entry for GLI1

1. General information

Official gene symbolGLI1
Entrez ID2735
Gene full nameGLI family zinc finger 1
Other gene symbolsGLI
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001649Osteoblast differentiationIDAbiological_process
GO:0003677DNA bindingIDA IEAmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0007224Smoothened signaling pathwayIDA TASbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0007418Ventral midline developmentIEAbiological_process
GO:0008017Microtubule bindingIEAmolecular_function
GO:0008284Positive regulation of cell proliferationIMPbiological_process
GO:0008589Regulation of smoothened signaling pathwayTASbiological_process
GO:0009913Epidermal cell differentiationIDAbiological_process
GO:0009953Dorsal/ventral pattern formationIEAbiological_process
GO:0009954Proximal/distal pattern formationIEAbiological_process
GO:0021696Cerebellar cortex morphogenesisIEAbiological_process
GO:0021938Smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferationIEAbiological_process
GO:0021983Pituitary gland developmentIEAbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045740Positive regulation of DNA replicationIDAbiological_process
GO:0045880Positive regulation of smoothened signaling pathwayIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048546Digestive tract morphogenesisTASbiological_process
GO:0060032Notochord regressionIEAbiological_process
GO:0072372Primary ciliumIEAcellular_component
GO:0090090Negative regulation of canonical Wnt signaling pathwayIMPbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.75995586030.29884489570.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0221703072
GSE13712_SHEARDown-0.6322531255
GSE13712_STATICUp0.2389291425
GSE19018Up0.2077546151
GSE19899_A1Down-0.0508898437
GSE19899_A2Up0.0383650298
PubMed_21979375_A1Down-0.2591843099
PubMed_21979375_A2Down-0.2312651720
GSE35957Down-0.1933990242
GSE36640Down-0.4157574073
GSE54402Up0.1522049495
GSE9593Up0.0666654733
GSE43922Up0.0504614564
GSE24585Down-0.1097438432
GSE37065Up0.0233681232
GSE28863_A1Down-0.0744507162
GSE28863_A2Up0.0117998330
GSE28863_A3Up0.3415185045
GSE28863_A4Down-0.0552975120
GSE48662Down-0.0562746447

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-326MIMAT0000756MIRT000082Luciferase reporter assayFunctional MTI18756266
hsa-miR-125b-5pMIMAT0000423MIRT000350Luciferase reporter assayFunctional MTI18756266
hsa-miR-324-5pMIMAT0000761MIRT000530Luciferase reporter assay//Western blotFunctional MTI20216554
hsa-miR-324-5pMIMAT0000761MIRT000530Luciferase reporter assayFunctional MTI18756266
hsa-miR-335-5pMIMAT0000765MIRT017728MicroarrayFunctional MTI (Weak)18185580
Entries Per Page
Displaying Page of
  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-324-5pMIMAT00007611hsa-miR-324-5p{Western blot}{overexpression by miRNA mimics tranfection}18756266
Entries Per Page
Displaying Page of

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25645196LiCl treatment of MB spheres down-regulated the Hh target Gli1, whereas the repressive Gli3 protein (Gli3R) was increased
25645196Mechanistically, we show by co-immunoprecipitation and proximity ligation assay that stabilized beta-catenin physically interacts with Gli1, leading to Gli1 sequestration and inhibition of its transcriptional activity
25645196CONCLUSION: We propose that beta-catenin stabilization increases its physical interaction with Gli1, leading to Gli1 degradation and inhibition of Hh signaling, thereby promoting tumor cell senescence and suppression of "tumor take" in mice
17145814The expression of p16, beta-catenin, and Gli1 and the in vivo methylation status of the p16 gene were also analyzed in serial sections of colonic precancerous lesions
15136151Lack of Sonic hedgehog (Shh) signaling, mediated by the Gli proteins, leads to severe pulmonary hypoplasia
15136151However, the precise role of Gli genes in lung development is not well established
Entries Per Page
Displaying Page of