HCSGD entry for PRPF19

1. General information

Official gene symbolPRPF19
Entrez ID27339
Gene full namePRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
Other gene symbolsNMP200 PRP19 PSO4 SNEV UBOX4 hPSO4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000151Ubiquitin ligase complexIEAcellular_component
GO:0000209Protein polyubiquitinationIDAbiological_process
GO:0000245Spliceosomal complex assemblyIMPbiological_process
GO:0000398MRNA splicing, via spliceosomeIC IDAbiological_process
GO:0000974Prp19 complexIDAcellular_component
GO:0001833Inner cell mass cell proliferationIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0004842Ubiquitin-protein ligase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005811Lipid particleIEAcellular_component
GO:0005819SpindleIEAcellular_component
GO:0006281DNA repairIEAbiological_process
GO:0008610Lipid biosynthetic processIEAbiological_process
GO:0016607Nuclear speckIDAcellular_component
GO:0034450Ubiquitin-ubiquitin ligase activityIDAmolecular_function
GO:0042802Identical protein bindingIPImolecular_function
GO:0045665Negative regulation of neuron differentiationIEAbiological_process
GO:0048026Positive regulation of mRNA splicing, via spliceosomeIEAbiological_process
GO:0048711Positive regulation of astrocyte differentiationIEAbiological_process
GO:0071013Catalytic step 2 spliceosomeIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.16363257100.23620969570.80085029750.9361187716

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.7941950447
GSE13712_SHEARDown-0.0638014587
GSE13712_STATICDown-0.0185741055
GSE19018Up0.0539746999
GSE19899_A1Up0.0619172802
GSE19899_A2Up0.0146712451
PubMed_21979375_A1Down-0.4687568535
PubMed_21979375_A2Up0.3580186023
GSE35957Down-0.6740418752
GSE36640Down-1.1062254578
GSE54402Up0.1339738861
GSE9593Down-0.3692013379
GSE43922Down-0.0347594903
GSE24585Down-0.3952106303
GSE37065Down-0.3043403056
GSE28863_A1Up0.6238949808
GSE28863_A2Up0.4217344651
GSE28863_A3Up0.2754579460
GSE28863_A4Up0.1756278798
GSE48662Up0.1964338107

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT041329CLASHFunctional MTI (Weak)23622248
hsa-miR-30a-5pMIMAT0000087MIRT049927CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT051973CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26663487In this study, we used heterozygous SNEV(+/-) mice (SNEV-knockout results in early embryonic lethality) and wild-type littermate controls as a model to elucidate the role of SNEV(P) (rp19/) (PSO) (4) in DNA damage repair and senescence in vivo
26663487Thus, the DNA damage response occurring in the mouse skin upon PUVA treatment is dependent on SNEV(P) (rp19/) (PSO) (4) expression and lower levels of SNEV(P) (rp19/) (PSO) (4) , as in old SNEV(+/-) mice, result in increase in cellular senescence and acceleration of premature skin ageing
21639856The complex contains the splicing factor hPrp19, also known as SNEV or hPso4, which is involved in cellular life-span regulation and proteasomal breakdown
18083760Therefore, we summarize and discuss here that (i) systemic administration of anti-cancer chemotherapeutics, in many cases DNA cross-linking drugs, induces premature progeroid frailty in long-term survivors; (ii) that ICL-inducing 8-methoxy-psoralen/UVA phototherapy leads to signs of premature skin aging as prominent long-term side effect and (iii) that mutated factors involved in ICL repair like ERCC1/XPF, the Fanconi anaemia proteins, WRN and SNEV lead to reduced replicative life span in vitro and segmental progeroid syndromes in vivo
16332694SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly
16332694We have isolated the human protein SNEV as downregulated in replicatively senescent cells
16332694Sequence homology to the yeast splicing factor Prp19 suggested that SNEV might be the orthologue of Prp19 and therefore might also be involved in pre-mRNA splicing
16332694We have used various approaches including gene complementation studies in yeast using a temperature sensitive mutant with a pleiotropic phenotype and SNEV immunodepletion from human HeLa nuclear extracts to determine its function
16332694In addition, immunodepletion of SNEV from human nuclear extracts resulted in a decrease of in vitro pre-mRNA splicing efficiency
16332694Furthermore, as part of our analysis of protein-protein interactions within the CDC5L complex, we found that SNEV interacts with itself
16332694These results indicate that SNEV is the human orthologue of yeast PRP19, functions in splicing and that homo-oligomerization of SNEV in HeLa nuclear extract is essential for spliceosome assembly and that it might also be important for spliceosome stability
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