HCSGD entry for UBE2S
1. General information
| Official gene symbol | UBE2S |
|---|---|
| Entrez ID | 27338 |
| Gene full name | ubiquitin-conjugating enzyme E2S |
| Other gene symbols | E2-EPF E2EPF EPF5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005680 | Anaphase-promoting complex | IDA | cellular_component |
| GO:0006464 | Cellular protein modification process | TAS | biological_process |
| GO:0010458 | Exit from mitosis | IDA IMP | biological_process |
| GO:0010994 | Free ubiquitin chain polymerization | IDA | biological_process |
| GO:0016881 | Acid-amino acid ligase activity | IEA | molecular_function |
| GO:0031145 | Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0035519 | Protein K29-linked ubiquitination | IDA | biological_process |
| GO:0044314 | Protein K27-linked ubiquitination | IDA | biological_process |
| GO:0051488 | Activation of anaphase-promoting complex activity | IDA | biological_process |
| GO:0070534 | Protein K63-linked ubiquitination | IDA | biological_process |
| GO:0070979 | Protein K11-linked ubiquitination | IDA | biological_process |
| GO:0085020 | Protein K6-linked ubiquitination | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6364844953 | 0.0082980320 | 0.9999902473 | 0.1823142738 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5744812374 |
| GSE13712_SHEAR | Down | -0.1367951361 |
| GSE13712_STATIC | Down | -0.3127769101 |
| GSE19018 | Up | 0.0385489604 |
| GSE19899_A1 | Down | -0.9169160771 |
| GSE19899_A2 | Down | -0.5442929676 |
| PubMed_21979375_A1 | Up | 0.8793666013 |
| PubMed_21979375_A2 | Down | -1.5666095116 |
| GSE35957 | Down | -1.5592559649 |
| GSE36640 | Down | -1.5072371902 |
| GSE54402 | Up | 0.3009921755 |
| GSE9593 | Down | -0.6718114968 |
| GSE43922 | Up | 0.0283146094 |
| GSE24585 | Down | -0.5595167317 |
| GSE37065 | Down | -0.1079760681 |
| GSE28863_A1 | Down | -0.1313968312 |
| GSE28863_A2 | Up | 0.1243609313 |
| GSE28863_A3 | Up | 0.0069956200 |
| GSE28863_A4 | Up | 0.8302559217 |
| GSE48662 | Down | -0.1822415989 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT001401 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025286 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-484 | MIMAT0002174 | MIRT042126 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043221 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045572 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050848 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
