HCSGD entry for RPS6KA6

1. General information

Official gene symbolRPS6KA6
Entrez ID27330
Gene full nameribosomal protein S6 kinase, 90kDa, polypeptide 6
Other gene symbolsPP90RSK4 RSK4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIEAmolecular_function
GO:0004672Protein kinase activityTASmolecular_function
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIMPbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007417Central nervous system developmentTASbiological_process
GO:0045992Negative regulation of embryonic developmentISSbiological_process
GO:0070373Negative regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:2000381Negative regulation of mesoderm developmentISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.83318538430.08814245280.99999024730.5631061893

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0223130482
GSE13712_SHEARDown-0.0498914990
GSE13712_STATICUp0.1557621840
GSE19018Down-0.7422393249
GSE19899_A1Down-0.0240590446
GSE19899_A2Down-0.7913152345
PubMed_21979375_A1Down-0.2273959253
PubMed_21979375_A2Down-0.1774838934
GSE35957Down-0.0578829658
GSE36640Up0.6028525417
GSE54402Down-0.7492702192
GSE9593Up0.2210743570
GSE43922Down-0.1346530683
GSE24585Up0.5058094261
GSE37065Down-0.0110861883
GSE28863_A1Down-0.2410455806
GSE28863_A2Up0.1518982705
GSE28863_A3Down-0.5478625505
GSE28863_A4Down-0.0215664153
GSE48662Up0.0162411786

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017599MicroarrayFunctional MTI (Weak)18185580
hsa-miR-26b-5pMIMAT0000083MIRT029385MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.