HCSGD entry for APEX2
1. General information
| Official gene symbol | APEX2 |
|---|---|
| Entrez ID | 27301 |
| Gene full name | APEX nuclease (apurinic/apyrimidinic endonuclease) 2 |
| Other gene symbols | APE2 APEXL2 XTH2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity | IEA | molecular_function |
| GO:0004519 | Endonuclease activity | IEA | molecular_function |
| GO:0004527 | Exonuclease activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006310 | DNA recombination | IEA | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7300802135 | 0.1573040994 | 0.9999902473 | 0.7663524338 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0565007200 |
| GSE13712_SHEAR | Down | -0.2747034513 |
| GSE13712_STATIC | Down | -0.3232732703 |
| GSE19018 | Down | -0.0750286993 |
| GSE19899_A1 | Down | -0.0173977019 |
| GSE19899_A2 | Up | 0.4473289190 |
| PubMed_21979375_A1 | Up | 0.2437646113 |
| PubMed_21979375_A2 | Up | 0.0700020848 |
| GSE35957 | Down | -0.7354573557 |
| GSE36640 | Down | -0.6672493859 |
| GSE54402 | Up | 0.3938898468 |
| GSE9593 | Down | -0.2900248236 |
| GSE43922 | Up | 0.3512110466 |
| GSE24585 | Down | -0.3278388557 |
| GSE37065 | Up | 0.0271061159 |
| GSE28863_A1 | Down | -0.0629897634 |
| GSE28863_A2 | Up | 0.0181393233 |
| GSE28863_A3 | Down | -0.2212076838 |
| GSE28863_A4 | Down | -0.0561108433 |
| GSE48662 | Down | -0.1222330507 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002638 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002638 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
