HCSGD entry for AMPH
1. General information
| Official gene symbol | AMPH |
|---|---|
| Entrez ID | 273 |
| Gene full name | amphiphysin |
| Other gene symbols | AMPH1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005543 | Phospholipid binding | IDA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006897 | Endocytosis | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007612 | Learning | IEA | biological_process |
| GO:0008021 | Synaptic vesicle | TAS | cellular_component |
| GO:0015629 | Actin cytoskeleton | TAS | cellular_component |
| GO:0030054 | Cell junction | IEA | cellular_component |
| GO:0030672 | Synaptic vesicle membrane | IEA | cellular_component |
| GO:0031256 | Leading edge membrane | IDA | cellular_component |
| GO:0048488 | Synaptic vesicle endocytosis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9710727024 | 0.0013508643 | 0.9999902473 | 0.0712547094 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0273820516 |
| GSE13712_SHEAR | Down | -0.9150191059 |
| GSE13712_STATIC | Down | -2.0585424912 |
| GSE19018 | Down | -0.6233814753 |
| GSE19899_A1 | Down | -0.4688904729 |
| GSE19899_A2 | Down | -2.4508644303 |
| PubMed_21979375_A1 | Down | -1.6431630540 |
| PubMed_21979375_A2 | Down | -2.0759690648 |
| GSE35957 | Down | -0.4604309487 |
| GSE36640 | Down | -2.7318398066 |
| GSE54402 | Down | -0.0306358003 |
| GSE9593 | Up | 0.5922933957 |
| GSE43922 | Down | -0.7605810873 |
| GSE24585 | Up | 0.4289021122 |
| GSE37065 | Up | 0.4185143485 |
| GSE28863_A1 | Down | -0.0601330740 |
| GSE28863_A2 | Down | -0.0440181678 |
| GSE28863_A3 | Down | -0.3000928187 |
| GSE28863_A4 | Down | -0.1072095997 |
| GSE48662 | Down | -0.3033354720 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT052112 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 12044940 | Based on these results, it can be suggested that the functional deterioration of the senescent cells may be explained in terms of the down regulation of receptor mediated endocytosis, at least in part, and that the restoration of endocytosis apparatus either with amphiphysin supplementation or with reduction of caveolins might lead to functional recovery of the senescent cells |
| 11976184 | By adjusting the level of amphiphysin, we could modulate the efficiency of receptor-mediated endocytosis either in young or old cells toward growth factors: that is, a dominant negative mutant of amphiphysin-1 blocked the endocytosis in the young cells, while microinjection of the gene resumed its activity in the old cells |
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