HCSGD entry for GCLC

1. General information

Official gene symbolGCLC
Entrez ID2729
Gene full nameglutamate-cysteine ligase, catalytic subunit
Other gene symbolsGCL GCS GLCL GLCLC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000096Sulfur amino acid metabolic processTASbiological_process
GO:0000287Magnesium ion bindingIDAmolecular_function
GO:0004357Glutamate-cysteine ligase activityIDA IEA IMPmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIBAcellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0006534Cysteine metabolic processIDAbiological_process
GO:0006536Glutamate metabolic processIDAbiological_process
GO:0006750Glutathione biosynthetic processIDA IEA IMP TASbiological_process
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0006979Response to oxidative stressIDAbiological_process
GO:0008637Apoptotic mitochondrial changesIEAbiological_process
GO:0009408Response to heatIDAbiological_process
GO:0009410Response to xenobiotic stimulusIEAbiological_process
GO:0009725Response to hormoneIDAbiological_process
GO:0016595Glutamate bindingIDAmolecular_function
GO:0017109Glutamate-cysteine ligase complexIEAcellular_component
GO:0019852L-ascorbic acid metabolic processIEAbiological_process
GO:0031397Negative regulation of protein ubiquitinationIEAbiological_process
GO:0032436Positive regulation of proteasomal ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0043066Negative regulation of apoptotic processIDAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0043531ADP bindingIDAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045454Cell redox homeostasisIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0046685Response to arsenic-containing substanceIEAbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0050662Coenzyme bindingIPImolecular_function
GO:0050880Regulation of blood vessel sizeIMPbiological_process
GO:0051409Response to nitrosative stressIEAbiological_process
GO:0051900Regulation of mitochondrial depolarizationIEAbiological_process
GO:1901687Glutathione derivative biosynthetic processTASbiological_process
GO:2001237Negative regulation of extrinsic apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01140029630.85000227950.27015148511.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4672286699
GSE13712_SHEARDown-0.0479279517
GSE13712_STATICDown-0.1450021444
GSE19018Up0.8673266958
GSE19899_A1Up0.3964868188
GSE19899_A2Down-0.0286502955
PubMed_21979375_A1Up0.3230485723
PubMed_21979375_A2Up0.6036631306
GSE35957Up1.0288921195
GSE36640Up0.9139449302
GSE54402Down-0.2349557182
GSE9593Up0.7831224055
GSE43922Up0.8552651540
GSE24585Down-0.2485535496
GSE37065Up0.0093679033
GSE28863_A1Down-0.1393495253
GSE28863_A2Down-0.2819067578
GSE28863_A3Down-0.0520701796
GSE28863_A4Down-0.1297086868
GSE48662Up0.5663496706

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Glutamic AcidDB00142 NUTR00027
L-CysteineDB00151 NUTR00018 | DB04443

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT021012ProteomicsFunctional MTI (Weak)18668040
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.