HCSGD entry for VENTX


1. General information

Official gene symbolVENTX
Entrez ID27287
Gene full nameVENT homeobox
Other gene symbolsHPX42B NA88A VENTX2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.43743694390.71094287070.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0268457466
GSE13712_SHEARUp0.0060535175
GSE13712_STATICDown-0.0459568445
GSE19018Down-0.0287540669
GSE19899_A1Down-0.0099880767
GSE19899_A2Down-0.0433430303
PubMed_21979375_A1Up0.0632309987
PubMed_21979375_A2Down-0.0439983501
GSE35957Up0.0073773216
GSE36640Up0.0489649839
GSE54402Up0.5488172474
GSE9593Down-0.1173697590
GSE43922Down-0.0417032662
GSE24585Up0.0021082467
GSE37065Down-0.1613370772
GSE28863_A1Down-0.2004776627
GSE28863_A2Up0.0730849575
GSE28863_A3Up0.5916129412
GSE28863_A4Up0.0968821244
GSE48662Up0.0363377523

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21325273VentX trans-activates p53 and p16ink4a to regulate cellular senescence
21325273Using methods of reverse genetics, we recently identified VentX, a human homolog of the vertebrate Xenopus Vent family of homeobox genes, as a novel Wnt repressor and a putative tumor suppressor in lymphocytic leukemia
21325273Here, we show that VentX is a direct transcriptional activator of p53-p21 and p16ink4a-Rb tumor suppression pathways
21325273Conversely, inhibition of VentX expression by RNA interference ameliorated chemotherapeutic agent-induced senescence in lymphocytic leukemia cells
21325273The results of our study further reveal the mechanisms underlying tumor suppression function of VentX and suggest a role of VentX as a potential target in cancer prevention and treatment
Entries Per Page
Displaying Page of