HCSGD entry for VENTX
1. General information
Official gene symbol | VENTX |
---|---|
Entrez ID | 27287 |
Gene full name | VENT homeobox |
Other gene symbols | HPX42B NA88A VENTX2 |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network

This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
GO:0005634 | Nucleus | IEA | cellular_component |
GO:0007275 | Multicellular organismal development | IEA | biological_process |
GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.4374369439 | 0.7109428707 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Up | 0.0268457466 |
GSE13712_SHEAR | Up | 0.0060535175 |
GSE13712_STATIC | Down | -0.0459568445 |
GSE19018 | Down | -0.0287540669 |
GSE19899_A1 | Down | -0.0099880767 |
GSE19899_A2 | Down | -0.0433430303 |
PubMed_21979375_A1 | Up | 0.0632309987 |
PubMed_21979375_A2 | Down | -0.0439983501 |
GSE35957 | Up | 0.0073773216 |
GSE36640 | Up | 0.0489649839 |
GSE54402 | Up | 0.5488172474 |
GSE9593 | Down | -0.1173697590 |
GSE43922 | Down | -0.0417032662 |
GSE24585 | Up | 0.0021082467 |
GSE37065 | Down | -0.1613370772 |
GSE28863_A1 | Down | -0.2004776627 |
GSE28863_A2 | Up | 0.0730849575 |
GSE28863_A3 | Up | 0.5916129412 |
GSE28863_A4 | Up | 0.0968821244 |
GSE48662 | Up | 0.0363377523 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
---|---|
21325273 | VentX trans-activates p53 and p16ink4a to regulate cellular senescence |
21325273 | Using methods of reverse genetics, we recently identified VentX, a human homolog of the vertebrate Xenopus Vent family of homeobox genes, as a novel Wnt repressor and a putative tumor suppressor in lymphocytic leukemia |
21325273 | Here, we show that VentX is a direct transcriptional activator of p53-p21 and p16ink4a-Rb tumor suppression pathways |
21325273 | Conversely, inhibition of VentX expression by RNA interference ameliorated chemotherapeutic agent-induced senescence in lymphocytic leukemia cells |
21325273 | The results of our study further reveal the mechanisms underlying tumor suppression function of VentX and suggest a role of VentX as a potential target in cancer prevention and treatment |
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