HCSGD entry for ARHGEF16

1. General information

Official gene symbolARHGEF16
Entrez ID27237
Gene full nameRho guanine nucleotide exchange factor (GEF) 16
Other gene symbolsGEF16 NBR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005089Rho guanyl-nucleotide exchange factor activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0017048Rho GTPase bindingIPImolecular_function
GO:0030165PDZ domain bindingIPImolecular_function
GO:0030971Receptor tyrosine kinase bindingIPImolecular_function
GO:0032863Activation of Rac GTPase activityIMPbiological_process
GO:0032864Activation of Cdc42 GTPase activityIDAbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0060326Cell chemotaxisIMPbiological_process
GO:0090004Positive regulation of establishment of protein localization to plasma membraneIMPbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.65083387030.73020646630.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1085771000
GSE13712_SHEARDown-0.0951555576
GSE13712_STATICDown-0.0885065518
GSE19018Down-0.0859544258
GSE19899_A1Up0.0578426352
GSE19899_A2Up0.1680670857
PubMed_21979375_A1Up0.0765639836
PubMed_21979375_A2Down-0.0016592934
GSE35957Up0.0224747370
GSE36640Down-0.0529431941
GSE54402Up0.0580459455
GSE9593Down-0.0743526200
GSE43922Up0.1805371170
GSE24585Up0.0299122413
GSE37065Down-0.0134294809
GSE28863_A1Down-0.2269845045
GSE28863_A2Up0.0192186481
GSE28863_A3Up0.3080515318
GSE28863_A4Up0.0957592593
GSE48662Up0.0993272064

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.