HCSGD entry for DISC1

1. General information

Official gene symbolDISC1
Entrez ID27185
Gene full namedisrupted in schizophrenia 1
Other gene symbolsC1orf136 SCZD9
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000226Microtubule cytoskeleton organizationIMPbiological_process
GO:0001764Neuron migrationIMPbiological_process
GO:0002052Positive regulation of neuroblast proliferationIGIbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005739MitochondrionIDAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005874MicrotubuleIEAcellular_component
GO:0008104Protein localizationIEAbiological_process
GO:0010975Regulation of neuron projection developmentIEAbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0021799Cerebral cortex radially oriented cell migrationIEAbiological_process
GO:0021846Cell proliferation in forebrainIEAbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0030177Positive regulation of Wnt signaling pathwayIGIbiological_process
GO:0031929TOR signalingIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0051560Mitochondrial calcium ion homeostasisIEAbiological_process
GO:0060070Canonical Wnt signaling pathwayIEAbiological_process
GO:0090128Regulation of synapse maturationIEAbiological_process
GO:2000060Positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.60312511680.90715622890.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0066957263
GSE13712_SHEARUp0.1856103074
GSE13712_STATICUp0.1168867817
GSE19018Down-0.0234786439
GSE19899_A1Up0.2830582355
GSE19899_A2Up0.1368983985
PubMed_21979375_A1Down-0.0682869322
PubMed_21979375_A2Down-0.0485586315
GSE35957Up0.0454472563
GSE36640Down-0.0890377426
GSE54402Up0.0646845934
GSE9593Up0.0096925175
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.0534677014
GSE28863_A2Up0.3606290705
GSE28863_A3Up0.0263950629
GSE28863_A4Down-0.1334411120
GSE48662Up0.0214086256

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT023117MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.