HCSGD entry for GLS2
1. General information
| Official gene symbol | GLS2 |
|---|---|
| Entrez ID | 27165 |
| Gene full name | glutaminase 2 (liver, mitochondrial) |
| Other gene symbols | GA GLS LGA hLGA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004359 | Glutaminase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0006520 | Cellular amino acid metabolic process | TAS | biological_process |
| GO:0006541 | Glutamine metabolic process | IEA | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007269 | Neurotransmitter secretion | TAS | biological_process |
| GO:0008652 | Cellular amino acid biosynthetic process | TAS | biological_process |
| GO:0014047 | Glutamate secretion | TAS | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0042981 | Regulation of apoptotic process | IMP | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0072593 | Reactive oxygen species metabolic process | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6853526652 | 0.4940069374 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0358213146 |
| GSE13712_SHEAR | Down | -0.0859941925 |
| GSE13712_STATIC | Down | -0.0715389776 |
| GSE19018 | Down | -0.0150888970 |
| GSE19899_A1 | Down | -0.0581256081 |
| GSE19899_A2 | Down | -0.0627167224 |
| PubMed_21979375_A1 | Up | 0.3472360200 |
| PubMed_21979375_A2 | Down | -0.1018010774 |
| GSE35957 | Down | -0.0852002374 |
| GSE36640 | Up | 0.0858762472 |
| GSE54402 | Up | 0.1491568242 |
| GSE9593 | Down | -0.1128120027 |
| GSE43922 | Up | 0.0225938055 |
| GSE24585 | Up | 1.1103597982 |
| GSE37065 | Down | -0.0960132691 |
| GSE28863_A1 | Down | -0.1357008759 |
| GSE28863_A2 | Down | -0.2490317746 |
| GSE28863_A3 | Up | 0.1205652515 |
| GSE28863_A4 | Up | 0.0646112411 |
| GSE48662 | Down | -0.2900304300 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Glutamic Acid | DB00142 | NUTR00027 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016977 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26907686 | Additionally, we found that glutaminase 2 (GLS2), a modulator of p73-dependent antioxidant defense, is also involved in PCBP2-regulated ROS production |
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