HCSGD entry for AGO2
1. General information
| Official gene symbol | AGO2 |
|---|---|
| Entrez ID | 27161 |
| Gene full name | argonaute RISC catalytic component 2 |
| Other gene symbols | EIF2C2 Q10 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000340 | RNA 7-methylguanosine cap binding | IDA | molecular_function |
| GO:0000932 | Cytoplasmic mRNA processing body | IDA IEA | cellular_component |
| GO:0003729 | MRNA binding | IEA | molecular_function |
| GO:0003743 | Translation initiation factor activity | NAS | molecular_function |
| GO:0004521 | Endoribonuclease activity | EXP IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005844 | Polysome | IDA | cellular_component |
| GO:0005845 | MRNA cap binding complex | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006379 | MRNA cleavage | IEA | biological_process |
| GO:0006412 | Translation | NAS | biological_process |
| GO:0006413 | Translational initiation | NAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0009791 | Post-embryonic development | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016442 | RISC complex | IDA | cellular_component |
| GO:0030529 | Ribonucleoprotein complex | IDA | cellular_component |
| GO:0031047 | Gene silencing by RNA | IEA ISS | biological_process |
| GO:0031054 | Pre-miRNA processing | IDA | biological_process |
| GO:0035068 | Micro-ribonucleoprotein complex | IDA | cellular_component |
| GO:0035197 | SiRNA binding | IDA | molecular_function |
| GO:0035198 | MiRNA binding | IEA | molecular_function |
| GO:0035278 | Negative regulation of translation involved in gene silencing by miRNA | IDA IMP | biological_process |
| GO:0035279 | MRNA cleavage involved in gene silencing by miRNA | IDA IMP | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045947 | Negative regulation of translational initiation | IDA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0060213 | Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | IEA ISS | biological_process |
| GO:0070551 | Endoribonuclease activity, cleaving siRNA-paired mRNA | IDA | molecular_function |
| GO:0090501 | RNA phosphodiester bond hydrolysis | EXP IDA | biological_process |
| GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic | EXP IDA | biological_process |
| GO:1900153 | Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0055225523 | 0.6772262262 | 0.1961661269 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1824188730 |
| GSE13712_SHEAR | Up | 0.0471052889 |
| GSE13712_STATIC | Down | -0.1482249788 |
| GSE19018 | Down | -0.5842280592 |
| GSE19899_A1 | Up | 1.2570822834 |
| GSE19899_A2 | Up | 1.0819394957 |
| PubMed_21979375_A1 | Up | 1.8357531114 |
| PubMed_21979375_A2 | Up | 1.3802013695 |
| GSE35957 | Up | 0.1048986974 |
| GSE36640 | Down | -0.4518792321 |
| GSE54402 | Up | 1.3007911723 |
| GSE9593 | Down | -0.1308986164 |
| GSE43922 | Up | 0.8696310669 |
| GSE24585 | Down | -0.4275757692 |
| GSE37065 | Down | -0.0456976822 |
| GSE28863_A1 | Up | 0.6047715640 |
| GSE28863_A2 | Up | 0.5969974695 |
| GSE28863_A3 | Down | -0.1291509993 |
| GSE28863_A4 | Up | 0.0049766412 |
| GSE48662 | Down | -0.0740191528 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-376a-3p | MIMAT0000729 | MIRT007020 | Luciferase reporter assay | Functional MTI | 21556037 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024741 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026680 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT027394 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT031016 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031917 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-671-5p | MIMAT0003880 | MIRT039278 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039512 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045258 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30d-5p | MIMAT0000245 | MIRT047789 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT049935 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051431 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052006 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052575 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-107 | MIMAT0000104 | NA | hsa-miR-107 | {Western blot} | {overexpression by miRNA precursor transfection} | 20042474 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25789082 | Coenzyme Q10 inhibits the aging of mesenchymal stem cells induced by D-galactose through Akt/mTOR signaling |
| 25789082 | Recent studies have demonstrated that coenzyme Q10 (CoQ10) plays a positive role in organ and cellular aging |
| 24327963 | Coenzyme Q10 prevents accelerated cardiac aging in a rat model of poor maternal nutrition and accelerated postnatal growth |
| 24327963 | Using an established rodent model of low birth-weight and catch-up growth, we show here that post-weaning dietary supplementation with coenzyme Q10, a key component of the electron transport chain and a potent antioxidant rescued many of the detrimental effects of nutritional programming on cardiac aging |
| 23727324 | Clinical evidence demonstrates that ubiquinol-10, the reduced active form of coenzyme Q10 (CoQ10H(2)), improves endothelial function through its antioxidant and probably its anti-inflammatory properties |
| 23085987 | Wig1 controls the association of Argonaute2 (Ago2), a central component of the RNA-induced silencing complex (RISC), with target p21 mRNA via binding of the stem-loop structure near the microRNA (miRNA) target site |
| 22366686 | Here, we demonstrate that AGO2, RB1 and microRNAs (miRNAs), as exemplified here by let-7, physically and functionally interact to repress RB1/E2F-target genes in senescence, a process that we call senescence-associated transcriptional gene silencing (SA-TGS) |
| 22366686 | Herein, AGO2 acts as the effector protein for let-7-directed implementation of silent-state chromatin modifications at target promoters, and inhibition of the let-7/AGO2 effector complex perturbs the timely execution of senescence |
| 20403425 | The lipophilic antioxidants alpha-tocopherol and coenzyme Q10 reduce the replicative lifespan of Saccharomyces cerevisiae |
| 20403425 | A genetically modified K6001 strain of Saccharomyces cerevisiae was employed to determine the effect of several antioxidants, including D-erythroascorbic acid, alpha-tocopherol and coenzyme Q(10) on yeast cell replicative ageing |
| 20403425 | Supplementation with either coenzyme Q(10) alone, or in combination with alpha-tocopherol also led to a reduction in yeast replicative lifespan |
| 10416050 | Virgin olive oil and coenzyme Q10 protect heart mitochondria from peroxidative damage during aging |
| 10416050 | We have performed a preliminary study on male rats, 6 or 12 month old, fed with diets differing in the nature of the fat (virgin olive oil or sunflower oil) and/or with antioxidant supplementation (coenzyme Q10), analysing hydroperoxide and coenzyme Q9 and Q10 in heart mitochondria |
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