HCSGD entry for BBC3
1. General information
| Official gene symbol | BBC3 |
|---|---|
| Entrez ID | 27113 |
| Gene full name | BCL2 binding component 3 |
| Other gene symbols | JFY-1 JFY1 PUMA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001836 | Release of cytochrome c from mitochondria | IDA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IDA IEA | cellular_component |
| GO:0005741 | Mitochondrial outer membrane | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006915 | Apoptotic process | IEA TAS | biological_process |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | ISS | biological_process |
| GO:0008340 | Determination of adult lifespan | ISS | biological_process |
| GO:0032464 | Positive regulation of protein homooligomerization | IDA | biological_process |
| GO:0032471 | Negative regulation of endoplasmic reticulum calcium ion concentration | IDA | biological_process |
| GO:0034976 | Response to endoplasmic reticulum stress | IDA | biological_process |
| GO:0043525 | Positive regulation of neuron apoptotic process | ISS | biological_process |
| GO:0045926 | Negative regulation of growth | IMP | biological_process |
| GO:0051209 | Release of sequestered calcium ion into cytosol | IDA | biological_process |
| GO:0070059 | Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | ISS | biological_process |
| GO:0070245 | Positive regulation of thymocyte apoptotic process | ISS | biological_process |
| GO:0071456 | Cellular response to hypoxia | IEP | biological_process |
| GO:0090200 | Positive regulation of release of cytochrome c from mitochondria | IDA IGI | biological_process |
| GO:0097190 | Apoptotic signaling pathway | IDA | biological_process |
| GO:0097193 | Intrinsic apoptotic signaling pathway | TAS | biological_process |
| GO:0097194 | Execution phase of apoptosis | IDA | biological_process |
| GO:1900740 | Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | IDA TAS | biological_process |
| GO:2001056 | Positive regulation of cysteine-type endopeptidase activity | ISS | biological_process |
| GO:2001244 | Positive regulation of intrinsic apoptotic signaling pathway | IMP TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1106677064 | 0.9897076327 | 0.6876469729 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.0722868280 |
| GSE28863_A2 | Down | -0.1841788912 |
| GSE28863_A3 | Up | 0.3752522673 |
| GSE28863_A4 | Up | 0.1440838842 |
| GSE48662 | Up | 0.9736206902 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-221-3p | MIMAT0000278 | MIRT003367 | Immunohistochemistry//In situ hybridization//Luciferase reporter assay//Northern blot//Western blot | Functional MTI | 20813046 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT003367 | Reporter assay;Microarray | Non-Functional MTI | 20018759 |
| hsa-miR-483-3p | MIMAT0002173 | MIRT004500 | qRT-PCR//Luciferase reporter assay//Western blot//Northern blot | Functional MTI | 20388800 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT005369 | Immunohistochemistry//In situ hybridization//Luciferase reporter assay//Northern blot//Western blot | Functional MTI | 20813046 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT005915 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20886540 |
| hsa-miR-296-5p | MIMAT0000690 | MIRT006683 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21633093 |
| hsa-miR-504-5p | MIMAT0002875 | MIRT016253 | qRT-PCR | Non-Functional MTI (Weak) | 20542001 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-221-3p | MIMAT0000278 | 1 | hsa-miR-221 | {Western blot} | {downregulation} | 20813046 | |
| hsa-miR-222-3p | MIMAT0000279 | 1 | hsa-miR-222 | {Western blot} | {downregulation} | 20813046 | |
| hsa-miR-296-5p | MIMAT0000690 | 1 | hsa-miR-296 | {Western blot} | {overexpression by miRNA retinoic acid induction} | 21633093 | |
| hsa-miR-296-5p | MIMAT0000690 | 2 | hsa-miR-296 | {Western blot} | {overexpression by miRNA retinoic acid induction} | 21633093 | |
| hsa-miR-125b-5p | MIMAT0000423 | NA | hsa-miR-125b | 21935352 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
